P40084

PR
Gene name
RTR1 (YER139C)
Protein name
RNA polymerase II subunit B1 CTD phosphatase RTR1
Names
RNA polymerase II-associated protein 2 homolog RTR1, Regulator of transcription 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YER139C
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-226 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P40084

Entry ID Method Resolution Chain Position Source
5C2Y X-ray 260 A A/B 1-178 PDB
AF-P40084-F1 Predicted AlphaFoldDB

3 variants for P40084

Variant ID(s) Position Change Description Diseaes Association Provenance
s05-451221 6 D>E No SGRP
s05-451010 77 L>V No SGRP
s05-450568 224 R>K No SGRP

No associated diseases with P40084

1 regional properties for P40084

Type Name Position InterPro Accession
domain Rtr1/RPAP2 domain 50 - 136 IPR007308

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles constitutively between the cytoplasm and the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
RNA polymerase core enzyme binding Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.
RNA polymerase II CTD heptapeptide repeat phosphatase activity Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate.

2 GO annotations of biological process

Name Definition
dephosphorylation of RNA polymerase II C-terminal domain The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATIEDIKET ALIPFQKHRQ LSMHEAEVIT LEIIGLLCDS ECKDEKTLKY LGRFLTPDMY
70 80 90 100 110 120
QDLVDERNLN KRCGYPLCGK SPERIRDPFS MNDTTKKFLL ENNPYAYLSH YCSKFHFRCS
130 140 150 160 170 180
QFYQVQLSDE ALFARTGVHL FEDPEQDKHD IDFKVTLFEE LLREKASEED IKSLISGLKK
190 200 210 220
LGLNPDSGTT EKDDTELEDD LSKWLAQIKI VENDNPSILG DFTRED