P39995

PR
Gene name
EAF5 (YEL018W)
Protein name
Chromatin modification-related protein EAF5
Names
ESA1-associated factor 5
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YEL018W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-207 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P39995

Entry ID Method Resolution Chain Position Source
5Y81 EM 470 A H 1-279 PDB
AF-P39995-F1 Predicted AlphaFoldDB

2 variants for P39995

Variant ID(s) Position Change Description Diseaes Association Provenance
s05-121928 153 N>S No SGRP
s05-121966 166 I>V No SGRP

No associated diseases with P39995

5 regional properties for P39995

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatases domain 344 - 406 IPR000387
domain Protein-tyrosine phosphatase, catalytic 323 - 471 IPR003595
domain GRAM domain 29 - 143 IPR004182
domain Myotubularin-like, phosphatase domain 151 - 538 IPR010569
active_site Protein-tyrosine phosphatase, active site 373 - 383 IPR016130

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
NuA4 histone acetyltransferase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
nucleosome disassembly/reassembly complex A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication-dependent chromatin assembly The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation.
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
histone acetylation The modification of a histone by the addition of an acetyl group.
nucleosome disassembly The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKEVSELVV LQLIHTLISN KNEELVRNGG GINMIGNNLR ISLVKLTNEI QNNLLINELT
70 80 90 100 110 120
NLRRQSNVAN GNRKLGINDI LTIVKNLFPE YRTTLNDGQL SLHGLEMHDI EKLLDEKYDR
130 140 150 160 170 180
FKKTQVEQIR MMEDEILKNG IKTGASQLQP HANAGKSGSA GTSATITTTT PHMAHSMDPK
190 200 210 220 230 240
REKLLKLYRD TVLNKLESKT GNFQKLFKSP DGSIIKNEIN YEDIKNETPG SVHELQLILQ
250 260 270
KSITDGVMRK VIGTDDWKLA RQVQFELDDT VQFMRRALE