P39764

PR
Gene name
kinC
Protein name
Sporulation kinase C
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU14490
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P39764

Entry ID Method Resolution Chain Position Source
AF-P39764-F1 Predicted AlphaFoldDB

No variants for P39764

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P39764

No associated diseases with P39764

11 regional properties for P39764

Type Name Position InterPro Accession
domain PAS domain 76 - 198 IPR000014
domain PAS-associated, C-terminal 148 - 200 IPR000700
repeat PAC motif 149 - 191 IPR001610
domain Histidine kinase/HSP90-like ATPase 320 - 426 IPR003594
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 214 - 277 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 357 - 371 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 375 - 385 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 386 - 404 IPR004358-3
domain Signal transduction histidine kinase-related protein, C-terminal 410 - 423 IPR004358-4
domain Histidine kinase domain 221 - 426 IPR005467
domain PAS fold 79 - 188 IPR013767

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Membrane raft ; Multi-pass membrane protein
  • Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion
  • Lost from DRM in the absence of farnesyl diphosphate phosphatase YisP or when cells are treated with YisP inhibitor zaragozic acid
  • Colocalizes with FloT in DRMs (PubMed:20713508, PubMed:26297017)
  • Another study shows KinC foci are membrane assemblies of 85-110 nm, but found no evidence of colocalization of these foci with FloA or FloT (PubMed:27362352)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

2 GO annotations of biological process

Name Definition
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKYQARIIS IILAMIFIMF WDYLFYFIGK NPINWPVDIV YTAVTLVSVW MLAYYIDEKQ
70 80 90 100 110 120
QLVKKMKDNE WKYKQLSEEK NRIMDNLQEI VFQTNAKGEI TYLNQAWASI TGFSISECMG
130 140 150 160 170 180
TMYNDYFIKE KHVADHINTQ IQNKASSGMF TAKYVTKNGT IFWGEVHYKL YYDRDDQFTG
190 200 210 220 230 240
SLGTMSDITE RKEAEDELIE INERLARESQ KLSITSELAA GIAHEVRNPL TSVSGFLQIM
250 260 270 280 290 300
KTQYPDRKDY FDIIFSEIKR IDLVLSELLL LAKPQAITFK THQLNEILKQ VTTLLDTNAI
310 320 330 340 350 360
LSNIVIEKNF KETDGCMING DENQLKQVFI NIIKNGIEAM PKGGVVTIST AKTASHAVIS
370 380 390 400 410 420
VKDEGNGMPQ EKLKQIGKPF YSTKEKGTGL GLPICLRILK EHDGELKIES EAGKGSVFQV
VLPLKSDS