P39722
Gene name |
GEM1 (YAL048C) |
Protein name |
Mitochondrial Rho GTPase 1 |
Names |
GTPase EF-hand protein of mitochondria 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YAL048C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P39722
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P39722-F1 | Predicted | AlphaFoldDB |
2 variants for P39722
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s01-54676 | 39 | P>S | No | SGRP | |
| s01-53844 | 316 | R>K | No | SGRP |
No associated diseases with P39722
5 regional properties for P39722
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 330 - 365 | IPR002048 |
| domain | Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 | 369 - 436 | IPR013566 |
| domain | EF hand associated, type-2 | 264 - 331 | IPR013567 |
| domain | MIRO domain | 3 - 185 | IPR020860-1 |
| domain | MIRO domain | 446 - 611 | IPR020860-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| ERMES complex | A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. |
| integral component of mitochondrial outer membrane | The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| outer mitochondrial membrane protein complex | Any protein complex that is part of the outer mitochondrial membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| heme transport | The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| mitochondrion inheritance | The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| mitochondrion-endoplasmic reticulum membrane tethering | The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. |
| phospholipid homeostasis | Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell. |
| regulation of mitochondrion organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00246 | RHO4 | GTP-binding protein RHO4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZM83 | RHOT2 | Mitochondrial Rho GTPase 2 | Gallus gallus (Chicken) | PR |
| Q8IMX7 | Miro | Mitochondrial Rho GTPase | Drosophila melanogaster (Fruit fly) | PR |
| Q9MA88 | MIRO3 | Mitochondrial Rho GTPase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKETIRVVI | CGDEGVGKSS | LIVSLTKAEF | IPTIQDVLPP | ISIPRDFSSS | PTYSPKNTVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDTSDSDLIA | LDHELKSADV | IWLVYCDHES | YDHVSLFWLP | HFRSLGLNIP | VILCKNKCDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISNVNANAMV | VSENSDDDID | TKVEDEEFIP | ILMEFKEIDT | CIKTSAKTQF | DLNQAFYLCQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RAITHPISPL | FDAMVGELKP | LAVMALKRIF | LLSDLNQDSY | LDDNEILGLQ | KKCFNKSIDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NELNFIKDLL | LDISKHDQEY | INRKLYVPGK | GITKDGFLVL | NKIYAERGRH | ETTWAILRTF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HYTDSLCIND | KILHPRLVVP | DTSSVELSPK | GYRFLVDIFL | KFDIDNDGGL | NNQELHRLFK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CTPGLPKLWT | STNFPFSTVV | NNKGCITLQG | WLAQWSMTTF | LNYSTTTAYL | VYFGFQEDAR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LALQVTKPRK | MRRRSGKLYR | SNINDRKVFN | CFVIGKPCCG | KSSLLEAFLG | RSFSEEYSPT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IKPRIAVNSL | ELKGGKQYYL | ILQELGEQEY | AILENKDKLK | ECDVICLTYD | SSDPESFSYL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSLLDKFTHL | QDLPLVFVAS | KADLDKQQQR | CQIQPDELAD | ELFVNHPLHI | SSRWLSSLNE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LFIKITEAAL | DPGKNTPGLP | EETAAKDVDY | RQTALIFGST | VGFVALCSFT | LMKLFKSSKF |
| SK |