P39718

PR
Gene name
PEX22 (YAL055W)
Protein name
Peroxisome assembly protein 22
Names
Peroxin-22
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YAL055W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P39718

Entry ID Method Resolution Chain Position Source
2Y9M X-ray 260 A B 54-180 PDB
2Y9P X-ray 325 A B 54-180 PDB
4BWF X-ray 323 A B 54-180 PDB
AF-P39718-F1 Predicted AlphaFoldDB

15 variants for P39718

Variant ID(s) Position Change Description Diseaes Association Provenance
s01-42181 2 P>S No SGRP
s01-42187 4 P>S No SGRP
s01-42211 12 T>S No SGRP
s01-42244 23 A>T No SGRP
s01-42272 32 Y>F No SGRP
s01-42305 43 G>E No SGRP
s01-42307 44 A>T No SGRP
s01-42316 47 P>S No SGRP
s01-42323 49 G>D No SGRP
s01-42422 82 A>V No SGRP
s01-42471 98 M>I No SGRP
s01-42485 103 G>E No SGRP
s01-42563 129 R>K No SGRP
s01-42685 170 V>I No SGRP
s01-42691 172 D>N No SGRP

No associated diseases with P39718

No regional properties for P39718

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P39718

Functions

Description
EC Number
Subcellular Localization
  • Peroxisome membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
peroxisomal membrane The lipid bilayer surrounding a peroxisome.

1 GO annotations of molecular function

Name Definition
ubiquitin-protein transferase activator activity Binds to and increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.

3 GO annotations of biological process

Name Definition
positive regulation of protein autoubiquitination Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.
positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
protein import into peroxisome matrix, receptor recycling The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD SVKENKKARK
70 80 90 100 110 120
SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ AIGDAFRKTK NEHKIIYCDS
130 140 150 160 170
MDGLWSCVRR LGKFQCILNS RDFTSSGGSD AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN