P39707

PR
Gene name
SEN34 (YAR008W, FUN4)
Protein name
tRNA-splicing endonuclease subunit SEN34
Names
Splicing endonuclease of 34 kDa, tRNA-intron endonuclease SEN34
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YAR008W
EC number
4.6.1.16: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

75-196 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P39707

Entry ID Method Resolution Chain Position Source
AF-P39707-F1 Predicted AlphaFoldDB

7 variants for P39707

Variant ID(s) Position Change Description Diseaes Association Provenance
s01-159101 45 L>F No SGRP
s01-159165 67 D>H No SGRP
s01-159226 87 D>A No SGRP
s01-159350 128 K>N No SGRP
s01-159370 135 L>P No SGRP
s01-159468 168 D>N No SGRP
s01-159528 188 A>P No SGRP

No associated diseases with P39707

1 regional properties for P39707

Type Name Position InterPro Accession
domain tRNA intron endonuclease, catalytic domain-like 183 - 271 IPR006677

Functions

Description
EC Number 4.6.1.16 Phosphorus-oxygen lyases
Subcellular Localization
  • Nucleus
  • Endomembrane system ; Peripheral membrane protein
  • Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria, suggesting that tRNA splicing mainly takes place on the mitochondrial surface
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
tRNA-intron endonuclease complex A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.

3 GO annotations of molecular function

Name Definition
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
nucleic acid binding Binding to a nucleic acid.
tRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.

1 GO annotations of biological process

Name Definition
tRNA-type intron splice site recognition and cleavage RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPLVFDIDH IKLLRKWGIC GVLSGTLPTA AQQNVFLSVP LRLMLEDVLW LHLNNLADVK
70 80 90 100 110 120
LIRQEGDEIM EGITLERGAK LSKIVNDRLN KSFEYQRKFK KDEHIAKLKK IGRINDKTTA
130 140 150 160 170 180
EELQRLDKSS NNDQLIESSL FIDIANTSMI LRDIRSDSDS LSRDDISDLL FKQYRQAGKM
190 200 210 220 230 240
QTYFLYKALR DQGYVLSPGG RFGGKFIAYP GDPLRFHSHL TIQDAIDYHN EPIDLISMIS
250 260 270
GARLGTTVKK LWVIGGVAEE TKETHFFSIE WAGFG