P39594

PR
Gene name
thiE (thiC, ywbK, BSU38290, ipa-26d)
Protein name
Thiamine-phosphate synthase
Names
TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU38290
EC number
2.5.1.3: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

97-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P39594

Entry ID Method Resolution Chain Position Source
1G4E X-ray 160 A A/B 1-222 PDB
1G4P X-ray 250 A A/B 1-222 PDB
1G4S X-ray 170 A A/B 1-222 PDB
1G4T X-ray 155 A A/B 1-222 PDB
1G67 X-ray 140 A A/B 1-222 PDB
1G69 X-ray 150 A A/B 1-222 PDB
1G6C X-ray 140 A A/B 1-222 PDB
2TPS X-ray 125 A A/B 1-222 PDB
3O15 X-ray 195 A A 1-222 PDB
3O16 X-ray 210 A A 1-222 PDB
AF-P39594-F1 Predicted AlphaFoldDB

No variants for P39594

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P39594

No associated diseases with P39594

1 regional properties for P39594

Type Name Position InterPro Accession
domain Thiamine phosphate synthase/TenI 15 - 213 IPR022998

Functions

Description
EC Number 2.5.1.3 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine-phosphate diphosphorylase activity Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate.

2 GO annotations of biological process

Name Definition
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRISREMMK ELLSVYFIMG SNNTKADPVT VVQKALKGGA TLYQFREKGG DALTGEARIK
70 80 90 100 110 120
FAEKAQAACR EAGVPFIVND DVELALNLKA DGIHIGQEDA NAKEVRAAIG DMILGVSAHT
130 140 150 160 170 180
MSEVKQAEED GADYVGLGPI YPTETKKDTR AVQGVSLIEA VRRQGISIPI VGIGGITIDN
190 200 210 220
AAPVIQAGAD GVSMISAISQ AEDPESAARK FREEIQTYKT GR