P39406

PR
Gene name
rsmC (yjjT, b4371, JW4333)
Protein name
Ribosomal RNA small subunit methyltransferase C
Names
16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b4371
EC number
2.1.1.172: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P39406

Entry ID Method Resolution Chain Position Source
2PJD X-ray 210 A A 1-343 PDB
AF-P39406-F1 Predicted AlphaFoldDB

No variants for P39406

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P39406

No associated diseases with P39406

3 regional properties for P39406

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 265 - 271 IPR002052
domain Methyltransferase small domain 167 - 333 IPR007848
domain Methyltransferase small, N-terminal 8 - 162 IPR013675

Functions

Description
EC Number 2.1.1.172 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
16S rRNA (guanine(1207)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine.
nucleic acid binding Binding to a nucleic acid.
rRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine.

3 GO annotations of biological process

Name Definition
RNA folding The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure.
rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.
rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAFTPASEV LLRHSDDFEQ SRILFAGDLQ DDLPARLDTA ASRAHTQQFH HWQVLSRQMG
70 80 90 100 110 120
DNARFSLVAT ADDVADCDTL IYYWPKNKPE AQFQLMNLLS LLPVGTDIFV VGENRSGVRS
130 140 150 160 170 180
AEQMLADYAP LNKVDSARRC GLYFGRLEKQ PVFDAEKFWG EYSVDGLTVK TLPGVFSRDG
190 200 210 220 230 240
LDVGSQLLLS TLTPHTKGKV LDVGCGAGVL SVAFARHSPK IRLTLCDVSA PAVEASRATL
250 260 270 280 290 300
AANGVEGEVF ASNVFSEVKG RFDMIISNPP FHDGMQTSLD AAQTLIRGAV RHLNSGGELR
310 320 330 340
IVANAFLPYP DVLDETFGFH EVIAQTGRFK VYRAIMTRQA KKG