P38883
Gene name |
RIX1 (IPI2, YHR197W) |
Protein name |
Pre-rRNA-processing protein RIX1 |
Names |
Involved in processing IST2 protein 2, Ribosomal export protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR197W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P38883
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6YLE | EM | 330 A | C/D | 1-763 | PDB |
| 6YLH | EM | 310 A | 6/7 | 1-763 | PDB |
| AF-P38883-F1 | Predicted | AlphaFoldDB |
12 variants for P38883
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-494116 | 74 | T>I | No | SGRP | |
| s08-494155 | 87 | G>D | No | SGRP | |
| s08-494251 | 119 | T>I | No | SGRP | |
| s08-494766 | 291 | E>K | No | SGRP | |
| s08-494980 | 362 | H>R | No | SGRP | |
| s08-495151 | 419 | N>S | No | SGRP | |
| s08-495282 | 463 | V>M | No | SGRP | |
| s08-495342 | 483 | S>G | No | SGRP | |
| s08-495688 | 598 | I>T | No | SGRP | |
| s08-495741 | 616 | V>M | No | SGRP | |
| s08-496069 | 725 | S>N | No | SGRP | |
| s08-496090 | 732 | K>R | No | SGRP |
No associated diseases with P38883
1 regional properties for P38883
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pre-rRNA-processing protein RIX1, N-terminal | 9 - 200 | IPR012583 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Rix1 complex | A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| pre-replicative complex assembly involved in nuclear cell cycle DNA replication | The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation. |
| regulation of DNA-templated DNA replication initiation | Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
| ribosomal large subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEEFIAVST | LARNLEIAKG | NEFHTILATL | RSPVYINEQL | LKSELSFLVT | KILKLIRSGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DFDLWKGCHT | SVVTCAYNPL | VLSTHGGQLL | AAIYSRLEQK | TGFYSSVISS | SHGKQLFNTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISSVAIIIDL | MKNKPTLSRE | ALVPKLKAII | PTLITLSQYE | PELVLPVLQR | ILKRNTTTFK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFTNKFRTVL | INLIISDYAS | LGTKTQRLVC | ENFAYLHLLK | IQVSDTSDDE | TQAHHKIYAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SNWRTGLMSI | LSQFKPIIQL | CGEILDFEQD | NELYKLIKSL | PVIDESNNKE | EFLPSLKLDF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NAPLTLWEIP | QRLSLLADML | VAFISLPTPF | PIRVPLGGIN | SLCEVLLGVS | NKYLPLKKEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RHDNELNGVI | NTILPQIQFQ | GIRLWEIMVS | KYGKCGLSFF | EGILSSIELF | IPLKKKSNNE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IDFNVVGSLK | FEFATVFRLV | NMILSHLGHQ | LNIISVISQL | IEVALFLSHD | KTLIDSLFKN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RKSIMKQQTK | TKQSKRSKSA | EGAFSDIYTH | PELFVCKNSM | NWFNEINDFF | ITALNNWILP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| STPHIQILKY | SITQSLRLKE | RFGYIPESFV | NLLRCEVLHP | GSERVSILPI | AISLLKNIND |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DMFELLCHPK | VPVGMVYQLH | KPLDLGEDGE | VRDDINKKEV | ETNESSSNAN | TGLETLKALE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NLENVTIPEP | KHEVPKVVDD | TAIFKKRSVE | EVIERESTSS | HKKVKFVEET | TVDNGEELIV |
| 730 | 740 | 750 | 760 | ||
| KKAVSQTKEE | EKPMEDSEDE | EQEEFEIPAI | ELSDDEEEEE | EEE |