P38873
PR
Gene name |
KOG1 (LAS24, YHR186C, H9998.14) |
Protein name |
Target of rapamycin complex 1 subunit KOG1 |
Names |
TORC1 subunit KOG1, Kontroller of growth protein 1, Local anesthetic-sensitive protein 24, Regulatory-associated protein of TOR, Raptor |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR186C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P38873
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7PQH | EM | 387 A | A/B/G/J | 1-1557 | PDB |
| AF-P38873-F1 | Predicted | AlphaFoldDB |
20 variants for P38873
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-480480 | 65 | R>C | No | SGRP | |
| s08-479718 | 319 | T>P | No | SGRP | |
| s08-479345 | 443 | A>V | No | SGRP | |
| s08-479207 | 489 | N>S | No | SGRP | |
| s08-478719 | 652 | G>S | No | SGRP | |
| s08-478714 | 653 | M>I | No | SGRP | |
| s08-478587 | 696 | G>S | No | SGRP | |
| s08-478429 | 748 | D>E | No | SGRP | |
| s08-478314 | 787 | L>I | No | SGRP | |
| s08-478145 | 843 | S>F | No | SGRP | |
| s08-477858 | 939 | I>V | No | SGRP | |
| s08-477824 | 950 | R>Q | No | SGRP | |
| s08-477804 | 957 | S>P | No | SGRP | |
| s08-477793 | 960 | Q>H | No | SGRP | |
| s08-477792 | 961 | G>S | No | SGRP | |
| s08-477596 | 1026 | K>R | No | SGRP | |
| s08-477510 | 1055 | F>L | No | SGRP | |
| s08-477509 | 1055 | F>S | No | SGRP | |
| s08-477189 | 1162 | A>T | No | SGRP | |
| s08-476930 | 1248 | S>F | No | SGRP |
No associated diseases with P38873
7 regional properties for P38873
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HEAT repeat | 784 - 811 | IPR000357 |
| repeat | WD40 repeat | 1237 - 1284 | IPR001680-1 |
| repeat | WD40 repeat | 1329 - 1381 | IPR001680-2 |
| repeat | WD40 repeat | 1387 - 1440 | IPR001680-3 |
| repeat | WD40 repeat | 1442 - 1482 | IPR001680-4 |
| repeat | WD40 repeat | 1509 - 1548 | IPR001680-5 |
| domain | Raptor, N-terminal CASPase-like domain | 79 - 233 | IPR029347 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| TORC1 complex | A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| cellular response to starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of protein serine/threonine kinase activity | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
| regulation of autophagy | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| response to nutrient | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. |
| TOR signaling | The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPEIYGPQPL | KPLNTVMRHG | FEEQYQSDQL | LQSLANDFIF | YFDDKRHKTN | GNPIPEEDKQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDVNRYYQPI | TDWKIMKDRQ | KTVSAALLLC | LNLGVDPPDV | MKTHPCARVE | AWVDPLNFQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKKAIEQIGK | NLQAQYETLS | LRTRYKQSLD | PCVEDVKRFC | NSLRRTSKED | RILFHYNGHG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPKPTKSGEI | WVFNRGYTQY | IPVSLYDLQT | WLGAPCIFVY | DCNSAENILI | NFQKFVQKRI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDDEEGNHDV | AAPSPTSAYQ | DCFQLASCTS | DELLLMSPEL | PADLFSCCLT | CPIEISIRIF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LMQSPLKDSK | YKIFFENSTS | NQPFGDSKNS | FKSKIPNVNI | PGMLSDRRTP | LGELNWIFTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITDTIAWTSL | PRPLFKKLFR | HDLMIAALFR | NFLLAKRIMP | WYNCHPVSDP | ELPDSITTHP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MWKSWDLAMD | EVLTKIVIDL | KNAPPATALE | SQMILQQQET | LQNGGSSKSN | AQDTKAGSIQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TQSRFAVANL | STMSLVNNPA | LQSRKSISLQ | SSQQQLQQQQ | QQQQQFTGFF | EQNLTAFELW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKYASNVRHP | PEQLPIVLQV | LLSQVHRIRA | LVLLSRFLDL | GPWAVYLSLS | IGIFPYVLKL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQSPAPELKP | ILVFIWARIM | SIDYKNTQSE | LIKEKGYMYF | VTVLVPDWGV | NGMSATNGSA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MINSGNPLTM | TASQNINGPS | SRYYERQQGN | RTSNLGHNNL | PFYHSNDTTD | EQKAMAVFVL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ASFVRNFPLG | QKNCFSLELV | NKLCFYIDNS | EIPLLRQWCV | ILLGLLFADN | PLNRFVCMNT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GAVEILLKSL | KDPVPEVRTA | SIFALKHFIS | GFQDAEVILR | LQQEFEEQYQ | QLHSQLQHLQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NQSHLQQQQS | QQQQQHLEQQ | QMKIEKQIRH | CQVMQNQLEV | IDLRKLKRQE | IGNLISILPL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| INDGSSLVRK | ELVVYFSHIV | SRYSNFFIVV | VFNDLLEEIK | LLEKSDINTR | NTSDKYSVSQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GSIFYTVWKS | LLILAEDPFL | ENKELSKQVI | DYILLELSAH | KELGGPFAVM | EKFLLKRSSK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AHQTGKFGFN | SSQVQFVKSS | LRSFSPNERV | DNNAFKKEQQ | QHDPKISHPM | RTSLAKLFQS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LGFSESNSDS | DTQSSNTSMK | SHTSKKGPSG | LYLLNGNNNI | YPTAETPRFR | KHTEPLQLPL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NSSFLDYSRE | YFQEPQMKKQ | EADEPGSVEY | NARLWRRNRN | ETIIQETQGE | KKLSIYGNWS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| KKLISLNNKS | QPKLMKFAQF | EDQLITADDR | STITVFDWEK | GKTLSKFSNG | TPFGTKVTDL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| KLINEDDSAL | LLTGSSDGVI | KIYRDYQDVD | TFKIVSAWRG | LTDMLLTPRS | TGLLTEWLQI |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| RGSLLTTGDV | KVIRVWDAHT | ETVEVDIPAK | TSSLITSLTA | DQLAGNIFVA | GFADGSLRVY |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| DRRLDPRDSM | IRRWRAGNDK | QGVWINNVHL | QRGGYRELVS | GATNGVVELW | DIRSEDPVES |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FVDQNVTSQY | GSQQKPTTMT | CMQVHEHAPI | IATGTKQIKI | WTTSGDLLNS | FKNSHNNGVT |
| 1510 | 1520 | 1530 | 1540 | 1550 | |
| STLAATGIPK | SLSYSSTSDA | FLSSMAFHPH | RMMIAATNSH | DSIVNIYKCE | DERIDYF |