P38851
Gene name |
LAM1 |
Protein name |
Membrane-anchored lipid-binding protein LAM1 |
Names |
Lipid transfer protein anchored at membrane contact sites 1, Yeast suicide protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR155W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38851
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38851-F1 | Predicted | AlphaFoldDB |
12 variants for P38851
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-407238 | 45 | S>G | No | SGRP | |
| s08-407305 | 67 | T>I | No | SGRP | |
| s08-407640 | 179 | V>F | No | SGRP | |
| s08-407740 | 212 | D>A | No | SGRP | |
| s08-407926 | 274 | R>K | No | SGRP | |
| s08-408292 | 396 | Y>S | No | SGRP | |
| s08-408326 | 407 | D>E | No | SGRP | |
| s08-408678 | 525 | A>S | No | SGRP | |
| s08-409229 | 708 | E>D | No | SGRP | |
| s08-409407 | 768 | L>V | No | SGRP | |
| s08-409650 | 849 | N>H | No | SGRP | |
| s08-409695 | 864 | F>L | No | SGRP |
No associated diseases with P38851
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cortical endoplasmic reticulum | A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| sterol transporter activity | Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular sterol transport | The directed movement of sterols within cells. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHEHKAELRL | ITVALNEAST | DSPSFRASVN | YFHTRMESLS | SWMHSTVDYV | ENTYKPSFQD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FQRIKETLFS | QLLPSPILLS | NGFVSNQPYT | PLLVRDFTRD | VSDLSNTVMK | IILGDENSQY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAALSALSSD | AINPYFNKRK | TFEYYQRKYD | SFLTDFLAAT | NDGNTLIPQN | LQNETFKLVD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKHKYIEASL | DLTEAISLMK | VNLDKFLIET | IDIVRKNNVI | TTKDTKDVID | ITPELTETLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DWTDWIESNL | QTLQALSSKL | SEAKYAILKL | SLARMKPSRL | IQDYDLKSIQ | NLKFNLPKSI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNGNNSEEKG | LSGWLYMKTT | VGHDPKRVVW | VRRWCFLQNN | VFGVFSLSPS | KTYVEETDKF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GILWITVEYL | PKEPRNFCFK | LRIQNPNCKT | EEENTYIDII | LQAESIDELK | SWINTLTSHK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RIALSIKEEN | DPRYQLARKK | IEPQFFEFAS | SSSTSTDKLL | TSFSSKTLTL | VEELKKNYMS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EDDIYSIIDN | KAYHLRVIST | PIATQLTHLA | LFSTFLSVSN | YYPCATQANT | WGTANWNDLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YLVNPLKGSS | VHKPATVSNS | SRFSVSYPDY | YPYSLKVDDI | QFRSIFFSVN | HDFLQVPKEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLLRYSSVWC | PNNKQKFASM | AFVTLNHIYV | YLNISGFSYL | RRIDLLDIDS | IEYDKSPKHV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SSRMLHMQRG | DGLRFNMSVF | FTDRRAVASK | LQFLIENKAM | HIPKGEKEVL | EIFQELDEEI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ENEKKIIKDN | LSESEHYSKD | YDYLLKSTYD | HHFENTNETP | MELMSRKLRL | EREAWCYFQD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NFKVGSKTLF | HVLFGDKSQV | FPSSLFLCKK | GSNLNNNSYW | ERIRRAKEDA | SCQFELCRKL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QFQLNRTSNF | IKDLLWLKDD | NDNFKLVLQQ | RVTKIKQGYY | FEVEEGPIIV | KFPLCHPLLL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RVRFIIAECI | TSQGESLKKC | DLAILYDFNY | VESIDKLNTK | VEKLWLFERI | HLNWALRYCK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LEHSEINRKT | REYLKKFNDR | EKMSDVIKLC | GFLGVLPKER | IENDEKAGDF | MQPVYINYDF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LSLSKIFTKL | TVFYLSSVII | KTMKVLLAMV | MVIFKCFSKV | NKTLYYCLLI | SAVTNLFFVG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KSIHSYFSVK | SAETLFQNYA | NGDQRGLQIM | HRSLTVPDLN | LLTRKMMDND | QENPVFKRFD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| EDKNAYQYKG | TRQEIAIKRN | QVLTELKILQ | NTEKELVQGS | YRKFIITERD | KCITTQNEIF |
| 1210 | 1220 | ||||
| DLWINDTKLQ | DYCMACFAEY | NRLSAIPV |