AiPD: Autoinhibited Protein Database

Gene name	NMD2 (IFS1, SUA1, UPF2, YHR077C)
Protein name	Nonsense-mediated mRNA decay protein 2
Names	Up-frameshift suppressor 2
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YHR077C
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

229-401 (Predicted disordered autoinhibitory region) PR

229-401 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
4LUN	X-ray	164 A	U	1-310	PDB
AF-P38798-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s08-255206	147	F>Y	No	SGRP
s08-254861	262	R>K	No	SGRP
s08-254743	301	E>D	No	SGRP
s08-254649	333	P>S	No	SGRP
s08-254555	364	K>I	No	SGRP
s08-254382	422	D>Y	No	SGRP
s08-254160	496	Y>N	No	SGRP
s08-254001	549	S>G	No	SGRP
s08-253860	596	I>V	No	SGRP
s08-253830	606	D>N	No	SGRP
s08-253811	612	K>R	No	SGRP
s08-253700	649	R>K	No	SGRP
s08-253494	718	Y>D	No	SGRP
s08-253200	816	S>G	No	SGRP
s08-253196	817	K>R	No	SGRP
s08-253031	872	T>I	No	SGRP
s08-252970	892	E>D	No	SGRP
s08-252966	894	D>Y	No	SGRP
s08-252958	896	E>D	No	SGRP
s08-252904	914	E>D	No	SGRP

Type	Name	Position	InterPro Accession
domain	MIF4G-like, type 3	34 - 245	IPR003890-1
domain	MIF4G-like, type 3	373 - 561	IPR003890-2
domain	MIF4G-like, type 3	578 - 818	IPR003890-3
domain	Up-frameshift suppressor 2, C-terminal	964 - 1085	IPR007193

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
exon-exon junction complex	A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
polysome	A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
cytoplasmic RNA surveillance	The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm.
DNA recombination	Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins