P38773

PR
Gene name
DOG2
Protein name
2-deoxyglucose-6-phosphate phosphatase 2
Names
2-DOG-6-P 2, 2-deoxyglucose-6-phosphatase 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YHR043C
EC number
3.1.3.68: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38773

Entry ID Method Resolution Chain Position Source
AF-P38773-F1 Predicted AlphaFoldDB

2 variants for P38773

Variant ID(s) Position Change Description Diseaes Association Provenance
s08-193238 101 D>N No SGRP
s08-193096 148 K>M No SGRP

No associated diseases with P38773

8 regional properties for P38773

Type Name Position InterPro Accession
domain Diacylglycerol kinase, accessory domain 575 - 749 IPR000756
domain Diacylglycerol kinase, catalytic domain 427 - 561 IPR001206
domain EF-hand domain 172 - 252 IPR002048
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 268 - 318 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 333 - 380 IPR002219-2
binding_site EF-Hand 1, calcium-binding site 230 - 242 IPR018247
domain Diacylglycerol kinase type I, N-terminal 5 - 172 IPR029477
domain Diacylglycerol kinase gamma, second protein kinase C conserved region 1 334 - 392 IPR047475

Functions

Description
EC Number 3.1.3.68 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
2-deoxyglucose-6-phosphatase activity Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
beta-phosphoglucomutase activity Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate.
metal ion binding Binding to a metal ion.
sugar-phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.

1 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPQFSVDLCL FDLDGTIVST TTAAESAWKK LCRQHGVDPV ELFKHSHGAR SQEMMKKFFP
70 80 90 100 110 120
KLDNTDNKGV LALEKDMADN YLDTVSLIPG AENLLLSLDV DTETQKKLPE RKWAIVTSGS
130 140 150 160 170 180
PYLAFSWFET ILKNVGKPKV FITGFDVKNG KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV
190 200 210 220 230 240
FEDAPVGIKA GKAMGAITVG ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN
NPLTRD