P38737
PR
Gene name |
ECM29 (YHL030W) |
Protein name |
Proteasome component ECM29 |
Names |
Extracellular mutant protein 29 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHL030W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38737
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38737-F1 | Predicted | AlphaFoldDB |
48 variants for P38737
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-40257 | 59 | A>V | No | SGRP | |
| s08-40398 | 106 | A>V | No | SGRP | |
| s08-40448 | 123 | P>S | No | SGRP | |
| s08-40539 | 153 | A>V | No | SGRP | |
| s08-40662 | 194 | V>A | No | SGRP | |
| s08-40971 | 297 | T>S | No | SGRP | |
| s08-40983 | 301 | T>M | No | SGRP | |
| s08-41192 | 371 | K>Q | No | SGRP | |
| s08-41243 | 388 | C>S | No | SGRP | |
| s08-41495 | 472 | G>C | No | SGRP | |
| s08-41553 | 491 | K>R | No | SGRP | |
| s08-41820 | 580 | L>W | No | SGRP | |
| s08-41882 | 601 | D>N | No | SGRP | |
| s08-41916 | 612 | R>L | No | SGRP | |
| s08-42063 | 661 | R>Q | No | SGRP | |
| s08-42084 | 668 | G>D | No | SGRP | |
| s08-42119 | 680 | L>I | No | SGRP | |
| s08-42203 | 708 | V>F | No | SGRP | |
| s08-42236 | 719 | N>D | No | SGRP | |
| s08-42236 | 719 | N>Y | No | SGRP | |
| s08-42401 | 774 | A>T | No | SGRP | |
| s08-42498 | 806 | I>T | No | SGRP | |
| s08-42572 | 831 | V>I | No | SGRP | |
| s08-42614 | 845 | A>T | No | SGRP | |
| s08-42644 | 855 | V>I | No | SGRP | |
| s08-42653 | 858 | T>A | No | SGRP | |
| s08-42752 | 891 | E>Q | No | SGRP | |
| s08-42848 | 923 | Y>H | No | SGRP | |
| s08-42878 | 933 | F>L | No | SGRP | |
| s08-42930 | 950 | I>T | No | SGRP | |
| s08-42944 | 955 | F>L | No | SGRP | |
| s08-43206 | 1042 | S>L | No | SGRP | |
| s08-43241 | 1054 | I>V | No | SGRP | |
| s08-43589 | 1170 | P>S | No | SGRP | |
| s08-43729 | 1216 | E>D | No | SGRP | |
| s08-43808 | 1243 | V>I | No | SGRP | |
| s08-43926 | 1282 | W>L | No | SGRP | |
| s08-44340 | 1420 | M>T | No | SGRP | |
| s08-44493 | 1471 | T>K | No | SGRP | |
| s08-44567 | 1496 | Y>H | No | SGRP | |
| s08-44609 | 1510 | P>S | No | SGRP | |
| s08-44949 | 1623 | Q>R | No | SGRP | |
| s08-44967 | 1629 | N>S | No | SGRP | |
| s08-45039 | 1653 | K>R | No | SGRP | |
| s08-45165 | 1695 | S>F | No | SGRP | |
| s08-45216 | 1712 | T>I | No | SGRP | |
| s08-45248 | 1723 | I>V | No | SGRP | |
| s08-45569 | 1830 | G>S | No | SGRP |
No associated diseases with P38737
No regional properties for P38737
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38737 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| proteasome complex | A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| proteasome assembly | The aggregation, arrangement and bonding together of a mature, active proteasome complex. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSISSDEAKE | KQLVEKAELR | LAIADSPQKF | ETNLQTFLPP | LLLKLASPHA | SVRTAVFSAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNLISRINTL | PQVQLPVRAL | IVQAKEPNLA | AQQDSTNVRL | YSLLLASKGI | DRLSLQDRQQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLPLVVSNIS | CLTGTVAARM | FHILLKLILE | WVAPQESSHE | QEEFVQFLQL | DNDGFSFLMR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFTRFFLLVP | SKQVQVSQQP | LSRGYTCPGL | SLTDVAFFTY | DAGVTFNKEQ | LNKFKKAIFQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FVCRGMAATQ | TIEQSPRMIE | LMEFLCVVST | DSTNLSDDAA | QFMKRFPMPY | ENEEFITFLQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLYIGNTANG | RPPVKAILQE | KILSILNRSH | FATTKAECIS | LICSIGLHSS | EYKLRSLTLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FIRHVAKLNY | KNLNPASSSP | SSTDFSTCIV | SLIRNNLHAE | GWPKLQLGPQ | TPAFNTAILQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RQLQYETLGD | ILKRDFELVS | DLSYIEFLFE | SLKNDLPQFR | SSIQESLLSL | VGHLSILPQQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKLKLKNLLR | KNLSIDEQQR | EDNNDAVNSI | MALKFVSIKF | TNAAFPFHDP | EARLFNIWGT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VRTNRFDIIE | ESFKGLQPFW | FRVNNASINT | SATVKTSDLL | GSHLSETEFP | PFREFLQVLI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DQLDSEAASI | TRKSLNNAVR | FSKQCLISNA | IYGKKTMVIQ | DEDWSVRIDK | ALELDDTVVS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RVNEMVQGMN | DDIFIRYLTL | LSNEFTATNS | KGEQIAIFPY | QDPIFGSVLL | TLLNFVSNNV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRRLEILVPD | LYHLVIMKFQ | SLSDNDLAVC | ATIIGIISTA | IADSTHVKRI | TKIAQSQTMA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ETYVASYVVP | RLYLKDQTNH | IESDSILNLL | NILTTHLSHP | GTNKDMILKL | VCQVTKFGLL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LQVSAQERKD | FLKKVMDTIQ | DKLINDVTAI | QTWSYLSLYS | TDLENSSLFQ | EKLLETNVSK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QNDFLFSVGE | SLSVVAGKWS | SKYLIKQIDI | PNFNVEIMQQ | KFPATNVTTI | LDEIFSGCDS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TKPSLRKASC | IWLLSYIQYL | GHLPEVSSKC | NDIHLRFMRF | LADRDEFIQD | SAARGLSLVY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EIGGSDLKES | MVKGLLKSFT | ESTAGSASTS | ATGISGSVSE | ETELFEPGVL | NTGDGSISTY |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KDILNLASEV | GDPALVYKFM | SLAKSSALWS | SRKGIAFGLG | AIMSKSSLEE | LLLKDQQTAK |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KLIPKLYRYR | FDPFQAVSRS | MTDIWNTLIP | ESSLTISLYF | NDILDELLCG | MANKEWRVRE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ASTSALLQLI | QSQPQEKFSE | KMLKIWTMAF | RTMDDIKDSV | REVGTKFTTV | LAKILARSID |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VEKGVNPTKS | KEILDNILPF | LWGPHGLNSD | AEEVRNFALT | TLIDLVKHSP | GAIKPFTPKL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| IYDFITLFSS | IEPQVINYLA | LNAANYNIDA | NVIDTQRKNG | VTNSPLFQTI | EKLINNSDDC |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| MMEEIINVVI | KASRKSVGLP | SKVASSLVII | ILVKRYSIEM | KPYSGKLLKV | CLTMFEDRNE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| SVNIAFAISM | GYLFKVSALD | KCIKYSEKLI | TKYFEPTSTE | NNKKVVGTAI | DSILNYAKSE |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| FDNVASVFMP | LIFIACNDED | KDLETLYNKI | WTEASSSGAG | TVKLYLPEIL | NVLCVNIKSN |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| DFSIRKTCAK | SVIQLCGGIN | DSIPYPQIVK | LFDISREALS | GRSWDGKEHI | VAALVSLTEK |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| FSQTVADNND | LQESINHVMY | TEVSRKSMKY | VKKILPLYAR | YINVNPQEET | ITFLIEKAKE |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| MIRLLGSESD | DSEGSIKQTS | DESTIKRIKP | NTEITQKSSK | ENIENEEYVI | NLLKVSVDIC |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| NNSKSRYPMN | LLEFIIDEIA | YLFHNDRIIH | TWRTQLAASE | IGISIVGRFS | TISSADFIQN |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| VGRLWDQTFP | INCNKETIEN | VKLQMIKFGG | LIIQKIPSLQ | NNIEENLRLL | NSIDSTSRIE |
| LELKNIGL |