P38723
PR
Gene name |
COS8 (YHL048W) |
Protein name |
Protein COS8 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHL048W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38723
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38723-F1 | Predicted | AlphaFoldDB |
115 variants for P38723
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-6408 | 3 | E>D | No | SGRP | |
| s08-6415 | 6 | V>I | No | SGRP | |
| s08-6415 | 6 | V>L | No | SGRP | |
| s08-6418 | 7 | K>E | No | SGRP | |
| s08-6419 | 7 | K>R | No | SGRP | |
| s08-6421 | 8 | D>N | No | SGRP | |
| s08-6426 | 9 | E>D | No | SGRP | |
| s08-6425 | 9 | E>G | No | SGRP | |
| s08-6445 | 16 | S>P | No | SGRP | |
| s08-6448 | 17 | F>V | No | SGRP | |
| s08-6456 | 19 | Q>H | No | SGRP | |
| s08-6455 | 19 | Q>R | No | SGRP | |
| s08-6464 | 22 | F>S | No | SGRP | |
| s08-6473 | 25 | T>I | No | SGRP | |
| s08-6490 | 31 | V>L | No | SGRP | |
| s08-6500 | 34 | N>S | No | SGRP | |
| s08-6504 | 35 | E>D | No | SGRP | |
| s08-6503 | 35 | E>G | No | SGRP | |
| s08-6502 | 35 | E>K | No | SGRP | |
| s08-6507 | 36 | L>F | No | SGRP | |
| s08-6505 | 36 | L>M | No | SGRP | |
| s08-6516 | 39 | F>L | No | SGRP | |
| s08-6514 | 39 | F>V | No | SGRP | |
| s08-6515 | 39 | F>Y | No | SGRP | |
| s08-6528 | 43 | I>M | No | SGRP | |
| s08-6527 | 43 | I>N | No | SGRP | |
| s08-6530 | 44 | Y>S | No | SGRP | |
| s08-6568 | 57 | L>V | No | SGRP | |
| s08-6580 | 61 | V>I | No | SGRP | |
| s08-6593 | 65 | L>P | No | SGRP | |
| s08-6598 | 67 | S>G | No | SGRP | |
| s08-6599 | 67 | S>N | No | SGRP | |
| s08-6601 | 68 | N>D | No | SGRP | |
| s08-6606 | 69 | W>C | No | SGRP | |
| s08-6607 | 70 | I>V | No | SGRP | |
| s08-6611 | 71 | H>L | No | SGRP | |
| s08-6610 | 71 | H>Y | No | SGRP | |
| s08-6613 | 72 | P>S | No | SGRP | |
| s08-6620 | 74 | I>K | No | SGRP | |
| s08-6623 | 75 | V>A | No | SGRP | |
| s08-6628 | 77 | L>I | No | SGRP | |
| s08-6631 | 78 | L>F | No | SGRP | |
| s08-6635 | 79 | V>G | No | SGRP | |
| s08-6634 | 79 | V>L | No | SGRP | |
| s08-6641 | 81 | F>S | No | SGRP | |
| s08-6650 | 84 | P>L | No | SGRP | |
| s08-6652 | 85 | F>I | No | SGRP | |
|
s08-6654 s08-6652 |
85 | F>L | No | SGRP | |
| s08-6653 | 85 | F>Y | No | SGRP | |
| s08-6655 | 86 | F>L | No | SGRP | |
| s08-6658 | 87 | V>F | No | SGRP | |
| s08-6658 | 87 | V>L | No | SGRP | |
| s08-6661 | 88 | L>F | No | SGRP | |
| s08-6662 | 88 | L>R | No | SGRP | |
| s08-6665 | 89 | V>G | No | SGRP | |
| s08-6669 | 90 | I>M | No | SGRP | |
| s08-6670 | 91 | C>S | No | SGRP | |
| s08-6674 | 92 | G>A | No | SGRP | |
| s08-6676 | 93 | L>F | No | SGRP | |
| s08-6687 | 96 | K>N | No | SGRP | |
| s08-6685 | 96 | K>Q | No | SGRP | |
| s08-6686 | 96 | K>R | No | SGRP | |
| s08-6691 | 98 | S>A | No | SGRP | |
| s08-6707 | 103 | L>H | No | SGRP | |
| s08-6710 | 104 | I>T | No | SGRP | |
| s08-6719 | 107 | C>S | No | SGRP | |
| s08-6727 | 110 | I>V | No | SGRP | |
| s08-6733 | 112 | E>K | No | SGRP | |
| s08-6736 | 113 | D>N | No | SGRP | |
| s08-6739 | 114 | T>P | No | SGRP | |
| s08-6772 | 125 | V>I | No | SGRP | |
| s08-6798 | 133 | F>L | No | SGRP | |
| s08-6811 | 138 | T>A | No | SGRP | |
| s08-6824 | 142 | K>R | No | SGRP | |
| s08-6847 | 150 | S>G | No | SGRP | |
| s08-6848 | 150 | S>I | No | SGRP | |
| s08-6849 | 150 | S>R | No | SGRP | |
| s08-6856 | 153 | K>E | No | SGRP | |
| s08-6866 | 156 | K>R | No | SGRP | |
| s08-6907 | 170 | S>A | No | SGRP | |
| s08-6946 | 183 | I>V | No | SGRP | |
| s08-6961 | 188 | Q>E | No | SGRP | |
| s08-7060 | 221 | A>T | No | SGRP | |
| s08-7061 | 221 | A>V | No | SGRP | |
| s08-7084 | 229 | I>V | No | SGRP | |
| s08-7103 | 235 | N>S | No | SGRP | |
| s08-7102 | 235 | N>Y | No | SGRP | |
| s08-7106 | 236 | L>R | No | SGRP | |
| s08-7112 | 238 | C>F | No | SGRP | |
| s08-7117 | 240 | P>A | No | SGRP | |
| s08-7118 | 240 | P>Q | No | SGRP | |
| s08-7118 | 240 | P>R | No | SGRP | |
| s08-7127 | 243 | L>P | No | SGRP | |
| s08-7130 | 244 | Y>C | No | SGRP | |
| s08-7139 | 247 | L>* | No | SGRP | |
| s08-7140 | 247 | L>F | No | SGRP | |
| s08-7151 | 251 | T>M | No | SGRP | |
| s08-7154 | 252 | S>F | No | SGRP | |
| s08-7156 | 253 | G>R | No | SGRP | |
| s08-7163 | 255 | A>D | No | SGRP | |
| s08-7167 | 256 | D>E | No | SGRP | |
| s08-7175 | 259 | S>L | No | SGRP | |
| s08-7190 | 264 | P>L | No | SGRP | |
| s08-7204 | 269 | F>L | No | SGRP | |
| s08-7208 | 270 | I>T | No | SGRP | |
| s08-7207 | 270 | I>V | No | SGRP | |
| s08-7213 | 272 | T>A | No | SGRP | |
| s08-7214 | 272 | T>M | No | SGRP | |
| s08-7216 | 273 | R>G | No | SGRP | |
| s08-7220 | 274 | D>V | No | SGRP | |
| s08-7219 | 274 | D>Y | No | SGRP | |
| s08-7226 | 276 | Q>R | No | SGRP | |
| s08-7261 | 288 | E>K | No | SGRP | |
| s08-7386 | 329 | E>D | No | SGRP | |
| s08-7425 | 342 | R>S | No | SGRP |
No associated diseases with P38723
No regional properties for P38723
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38723 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKENEVKDEK | SVDVLSFKQL | EFQKTVLPQD | VFRNELTWFC | YEIYKSLAFR | IWMLLWLPLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VWWKLSSNWI | HPLIVSLLVL | FLGPFFVLVI | CGLSRKRSLS | KQLIQFCKEI | TEDTPSSDPH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DWEVVAANLN | SYFYENKTWN | TKYFFFNAMS | CQKAFKTTLL | EPFSLKKDES | AKVKSFKDSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PYIEEALQVY | AAGFDKEWKL | FNTEKEESPF | DLEDIQLPKE | AYRFKLTWIL | KRIFNLRCLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFLYYFLIVY | TSGNADLISR | FLFPVVMFFI | MTRDFQNMRM | IVLSVKMEHK | MQFLSTIINE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QESGANGWDE | IAKKMNRYLF | EKKVWNNEEF | FYDGLDCEWF | FRRFFYRLLS | LKKPMWFASL |
| 370 | 380 | ||||
| NVELWPYIKE | AQSARNEKPL | K |