P38635
Gene name |
HIS2 (YFR025C) |
Protein name |
Histidinol-phosphatase |
Names |
HolPase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YFR025C |
EC number |
3.1.3.15: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38635
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38635-F1 | Predicted | AlphaFoldDB |
10 variants for P38635
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s06-204669 | 24 | D>N | No | SGRP | |
| s06-204555 | 62 | V>F | No | SGRP | |
| s06-204548 | 64 | T>S | No | SGRP | |
| s06-204428 | 104 | D>G | No | SGRP | |
| s06-204377 | 121 | I>T | No | SGRP | |
| s06-204333 | 136 | P>A | No | SGRP | |
| s06-204270 | 157 | H>D | No | SGRP | |
| s06-203994 | 249 | R>G | No | SGRP | |
| s06-203796 | 315 | L>V | No | SGRP | |
| s06-203787 | 318 | V>I | No | SGRP |
No associated diseases with P38635
8 regional properties for P38635
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 83 - 112 | IPR001039-1 |
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 114 - 130 | IPR001039-2 |
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 134 - 151 | IPR001039-3 |
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 180 - 198 | IPR001039-4 |
| conserved_site | Immunoglobulin/major histocompatibility complex, conserved site | 280 - 286 | IPR003006 |
| domain | Immunoglobulin C1-set | 217 - 292 | IPR003597 |
| domain | Immunoglobulin-like domain | 207 - 296 | IPR007110 |
| domain | MHC class I-like antigen recognition-like | 27 - 200 | IPR011161 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.15 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histidinol-phosphatase activity | Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHSHHSHSGD | YSAHGTDPLD | SVVDQVVNLN | FHTYCLTEHI | PRIEAKFIYP | EEQSLGKNPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVITKLETSF | KNFMSHAQEI | KTRYADRPDV | RTKFIIGMEI | ESCDMAHIEY | AKRLMKENND |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILKFCVGSVH | HVNGIPIDFD | QQQWYNSLHS | FNDNLKHFLL | SYFQSQYEML | INIKPLVVGH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FDLYKLFLPN | DMLVNQKSGN | CNEETGVPVA | SLDVISEWPE | IYDAVVRNLQ | FIDSYGGAIE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| INTSALRKRL | EEPYPSKTLC | NLVKKHCGSR | FVLSDDAHGV | AQVGVCYDKV | KKYIVDVLQL |
| 310 | 320 | 330 | |||
| EYICYLEESQ | SPENLLTVKR | LPISQFVNDP | FWANI |