P38544

PR
Gene name
ran-1
Protein name
GTP-binding nuclear protein Ran
Names
GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein
Species
Onchocerca volvulus
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

144-215 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38544

Entry ID Method Resolution Chain Position Source
AF-P38544-F1 Predicted AlphaFoldDB

No variants for P38544

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P38544

No associated diseases with P38544

1 regional properties for P38544

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 9 - 157 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus envelope
  • Cytoplasm, cytosol
  • Cytoplasm
  • Predominantly nuclear during interphase
  • Becomes dispersed throughout the cytoplasm during mitosis (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATGDDIPTF KLVLVGDGGT GKTTFVKRHL TGDPEKKYVA TLGVEVHPLI FHTNRGQIRF
70 80 90 100 110 120
NVWDTAGQEK FGGLRDGYYI QGQCAIIMFD VTARVTYKNV PNWHRDLARV CENIPIVLCG
130 140 150 160 170 180
NFVDVKDRKV KAKTITFHRK KNLQYYDISA KSNYNFEKPS LWLVRKLLGD PNLEFVAMPA
190 200 210
LAPPEVQMDP TMVAQYEQEI AAAANAELPD DDEDL