P38442
Gene name |
zot (VC_1458) |
Protein name |
Zona occludens toxin |
Names |
Zonular occludens toxin, Zot |
Species |
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
KEGG Pathway |
vch:VC_1458 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38442
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38442-F1 | Predicted | AlphaFoldDB |
6 variants for P38442
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 45 | M>I | strain: 569B [UniProt] | No | ||
| 100 | V>A | strain: 569B and 86015 [UniProt] | No | ||
| 272 | V>A | strain: 569B [UniProt] | No | ||
| 281 | V>A | strain: 569B [UniProt] | No | ||
| 349 | A>S | strain: 86015 [UniProt] | No | ||
| 381 | K>R | strain: 86015 [UniProt] | No |
No associated diseases with P38442
10 regional properties for P38442
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 609 - 737 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 296 - 441 | IPR000909 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 492 - 609 | IPR001711 |
| domain | Pleckstrin homology domain | 19 - 132 | IPR001849 |
| domain | EF-hand domain | 140 - 175 | IPR002048 |
| domain | Phosphoinositide-specific phospholipase C, EF-hand-like domain | 204 - 288 | IPR015359 |
| binding_site | EF-Hand 1, calcium-binding site | 153 - 165 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 189 - 201 | IPR018247-2 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain | 295 - 596 | IPR028391 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain | 144 - 283 | IPR046975 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| toxin activity | Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIFIHHGAP | GSYKTSGALW | LRLLPAIKSG | RHIITNVRGL | NLERMAKYLK | MDVSDISIEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDTDHPDGRL | TMARFWHWAR | KDAFLFIDEC | GRIWPPRLTV | TNLKALDTPP | DLVAEDRPES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FEVAFDMHRH | HGWDICLTTP | NIAKVHNMIR | EAAEIGYRHF | NRATVGLGAK | FTLTTHDAAN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGQMDSHALT | RQVKKIPSPI | FKMYASTTTG | KARDTMAGTA | LWKDRKILFL | FGMVFLMFSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFYGLHDNPI | FTGGNDATIE | SEQSEPQSKA | TVGNAVGSKA | VAPASFGFCI | GRLCVQDGFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TVGDERYRLV | DNLDIPYRGL | WATGHHIYKD | TLTVFFETES | GSVPTELFAS | SYRYKVLPLP |
| 370 | 380 | 390 | |||
| DFNHFVVFDT | FAAQALWVEV | KRGLPIKTEN | DKKGLNSIF |