P38349
Gene name |
UBX7 (YBR273C, YBR1741) |
Protein name |
UBX domain-containing protein 7 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBR273C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38349
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38349-F1 | Predicted | AlphaFoldDB |
11 variants for P38349
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-749308 | 20 | E>G | No | SGRP | |
| s02-749309 | 20 | E>Q | No | SGRP | |
| s02-749098 | 90 | E>G | No | SGRP | |
| s02-749051 | 106 | A>T | No | SGRP | |
| s02-749021 | 116 | G>R | No | SGRP | |
| s02-748918 | 150 | T>I | No | SGRP | |
| s02-748625 | 248 | V>L | No | SGRP | |
| s02-748399 | 323 | H>R | No | SGRP | |
| s02-748313 | 352 | S>T | No | SGRP | |
| s02-748098 | 423 | N>K | No | SGRP | |
| s02-748061 | 436 | K>E | No | SGRP |
No associated diseases with P38349
1 regional properties for P38349
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | UBX domain | 209 - 292 | IPR001012 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| sporulation resulting in formation of a cellular spore | The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZBU9 | UBXN4 | UBX domain-containing protein 4 | Bos taurus (Bovine) | PR |
| Q92575 | UBXN4 | UBX domain-containing protein 4 | Homo sapiens (Human) | PR |
| Q8VCH8 | Ubxn4 | UBX domain-containing protein 4 | Mus musculus (Mouse) | PR |
| Q5HZY0 | Ubxn4 | UBX domain-containing protein 4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLEALFRDSV | EEAINDSIKE | GVVLAVYNTA | RDDQWLKSWF | KGDDVSLDTL | AEHSIWLRLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDTEQFQLFE | QVFPNVVVPS | IYLIRAGKIE | LIIQGEDDRH | WEKLLACIGI | KDKKAGESSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RETNPGLARE | EKSSRDVHRK | NARERIAETT | LEIQRREQLK | QRKLAEEERE | RIIRLVRADR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AERKALDETH | HRTLDDDKPL | DVHDYIKDAQ | KLHSSKCVLQ | IRMTDGKTLK | HEFNSSETLN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DVRKWVDVNR | TDGDCPYSFH | RGIPRVTFKD | SDELKTLETL | ELTPRSALLL | KPLETQNSGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVTGMEGPSL | LGRLYKGFST | WWHNDKDPEV | TSQREETSKP | NRHEVRSSTP | LSGAASSSCF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QYNNVREPVQ | SSAHASPMLT | PSGTRYPSET | NLTTSRSVSP | NVFQFVNNDH | QEDPEDPTTF |
| 430 | |||||
| NGNNVHLEKK | KDEDKK |