P38326
Gene name |
SWC5 (AOR1, YBR231C, YBR1529) |
Protein name |
SWR1-complex protein 5 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBR231C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P38326
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6KBB | X-ray | 237 A | E/F | 1-79 | PDB |
| AF-P38326-F1 | Predicted | AlphaFoldDB |
10 variants for P38326
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-683079 | 3 | E>K | No | SGRP | |
| s02-683027 | 20 | G>D | No | SGRP | |
| s02-682973 | 38 | G>D | No | SGRP | |
| s02-682936 | 50 | D>E | No | SGRP | |
| s02-682656 | 144 | T>A | No | SGRP | |
| s02-682514 | 191 | A>V | No | SGRP | |
| s02-682486 | 200 | K>N | No | SGRP | |
| s02-682457 | 210 | R>Q | No | SGRP | |
| s02-682311 | 259 | V>M | No | SGRP | |
| s02-682187 | 300 | S>N | No | SGRP |
No associated diseases with P38326
1 regional properties for P38326
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BCNT-C domain | 217 - 294 | IPR011421 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Swr1 complex | A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone exchange | The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPEVETKIIP | NEKEDEDEDG | YIEEEDEDFQ | PEKDKLGGGS | DDSDASDGGD | DYDDGVNRDK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRNKVDYSRI | ESESGGLIKT | RRARQAEEEY | AKTHKYESLT | VESIPAKVNS | IWEELQEASK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NRLLSSSGKV | GSVLDGSKEA | RSTTAAQQED | KILIERNYKF | AGETVHEKKW | VSRSSAEGQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLNSLKFKQQ | APAAPVQLEK | AVRTKSNESR | QHLRRPLKRP | PLLEQIISGG | LRPKLTTLEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQLDWASYVD | RAGLNDELVL | HNKDGFLARQ | EFLQRVGSAE | DERYKELRRQ | QLAQQLQQDS |
| EAS |