P38295

PR
Gene name
EHT1 (YBR177C, YBR1239)
Protein name
Medium-chain fatty acid ethyl ester synthase/esterase 2
Names
Alcohol O-acetyltransferase, Ethanol hexanoyl transferase 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR177C
EC number
2.3.1.84: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38295

Entry ID Method Resolution Chain Position Source
AF-P38295-F1 Predicted AlphaFoldDB

7 variants for P38295

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-586004 52 V>I No SGRP
s02-585904 85 K>R No SGRP
s02-585809 117 E>K No SGRP
s02-585803 119 D>N No SGRP
s02-585764 132 K>E No SGRP
s02-585650 170 I>V No SGRP
s02-585007 384 R>Q No SGRP

No associated diseases with P38295

2 regional properties for P38295

Type Name Position InterPro Accession
domain Alpha/beta hydrolase fold-1 166 - 430 IPR000073
conserved_site AB hydrolase 4, conserved site 354 - 395 IPR000952

Functions

Description
EC Number 2.3.1.84 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

6 GO annotations of molecular function

Name Definition
acetylesterase activity Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate.
acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
alcohol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.
alcohol O-butanoyltransferase activity Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester.
serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
short-chain carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.

3 GO annotations of biological process

Name Definition
cellular lipid metabolic process The chemical reactions and pathways involving lipids, as carried out by individual cells.
medium-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12.
medium-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEVSKWPAI NPFHWGYNGT VSHIVGENGS IKLHLKDNKE QVDFDEFANK YVPTLKNGAQ
70 80 90 100 110 120
FKLSPYLFTG ILQTLYLGAA DFSKKFPVFY GREIVKFSDG GVCTADWLID SWKKDYEFDQ
130 140 150 160 170 180
STTSFDKKKF DKDEKATHPE GWPRLQPRTR YLKDNELEEL REVDLPLVVI LHGLAGGSHE
190 200 210 220 230 240
PIIRSLAENL SRSGRFQVVV LNTRGCARSK ITTRNLFTAY HTMDIREFLQ REKQRHPDRK
250 260 270 280 290 300
LYAVGCSFGA TMLANYLGEE GDKSPLSAAA TLCNPWDLLL SAIRMSQDWW SRTLFSKNIA
310 320 330 340 350 360
QFLTRTVQVN MGELGVPNGS LPDHPPTVKN PSFYMFTPEN LIKAKSFKST REFDEVYTAP
370 380 390 400 410 420
ALGFPNAMEY YKAASSINRV DTIRVPTLVI NSRDDPVVGP DQPYSIVEKN PRILYCRTDL
430 440 450
GGHLAYLDKD NNSWATKAIA EFFTKFDELV V