P38261

PR
Gene name
EXO84 (USA3, YBR102C, YBR0831)
Protein name
Exocyst complex component EXO84
Names
Exocyst complex protein of 84 kDa, U1 SNP1-associating protein 3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR102C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-195 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P38261

Entry ID Method Resolution Chain Position Source
2D2S X-ray 285 A A 523-753 PDB
5YFP EM 440 A H 1-753 PDB
6VKL EM 440 A H 1-753 PDB
AF-P38261-F1 Predicted AlphaFoldDB

5 variants for P38261

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-447236 28 T>A No SGRP
s02-447019 100 I>T No SGRP
s02-446465 285 V>I No SGRP
s02-446401 306 L>R No SGRP
s02-446149 390 F>C No SGRP

No associated diseases with P38261

7 regional properties for P38261

Type Name Position InterPro Accession
domain FERM domain 1 - 279 IPR000299
domain Zinc finger, RING-type 387 - 422 IPR001841
domain FERM, N-terminal 5 - 67 IPR018979
domain FERM, C-terminal PH-like domain 194 - 283 IPR018980
domain FERM central domain 84 - 190 IPR019748
domain Band 4.1 domain 1 - 190 IPR019749
domain MYLIP, FERM domain C-lobe 185 - 295 IPR041790

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, secretory vesicle
  • Bud
  • Bud neck
  • Cell periphery, bud and bud neck
  • The polarization of EXO84 requires actin cables
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
cellular bud tip The end of a cellular bud distal to the site of attachment to the mother cell.
exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
incipient cellular bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
prospore membrane The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.
transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

9 GO annotations of biological process

Name Definition
exocyst assembly The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.
exocyst localization Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.
vesicle tethering involved in exocytosis The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVEFSLKKAR NNWKHVKKSA SSPAKQKTPP SPAKPKQKTK KNPYSDLKDP ATSYTLPTIN
70 80 90 100 110 120
ARERSRVATS MQRRLSIHNT NYAPPTLDYS MPLPDMPNMI VPNDNVDSSH NNSSFTTENE
130 140 150 160 170 180
SVSSKGPSNS LNLSTADLSL NDSSYNKVPA RSAMRNTVNP SGSNDPFNNS TSLRKMLANP
190 200 210 220 230 240
HFNAKDFVHD KLGNASAITI DKFTSNLTDL SIQVQEEVKL NINKSYNEIM TVNNDLNVAM
250 260 270 280 290 300
LELKRVRANI NDLNEVLDQC TKIAEKRLQL QDQIDQERQG NFNNVESHSN SPALLPPLKA
310 320 330 340 350 360
GQNGNLMRRD RSSVLILEKF WDTELDQLFK NVEGAQKFIN STKGRHILMN SANWMELNTT
370 380 390 400 410 420
TGKPLQMVQI FILNDLVLIA DKSRDKQNDF IVSQCYPLKD VTVTQEEFST KRLLFKFSNS
430 440 450 460 470 480
NSSLYECRDA DECSRLLDVI RKAKDDLCDI FHVEEENSKR IRESFRYLQS TQQTPGRENN
490 500 510 520 530 540
RSPNKNKRRS MGGSITPGRN VTGAMDQYLL QNLTLSMHSR PRSRDMSSTA QRLKFLDEGV
550 560 570 580 590 600
EEIDIELARL RFESAVETLL DIESQLEDLS ERISDEELML LNLISLKIEQ RREAISSKLS
610 620 630 640 650 660
QSILSSNEIV HLKSGTENMI KLGLPEQALD LFLQNRSNFI QDLILQIGSV DNPTNYLTQL
670 680 690 700 710 720
AVIRFQTIKK TVEDFQDIFK ELGAKISSIL VDWCSDEVDN HFKLIDKQLL NDEMLSPGSI
730 740 750
KSSRKQIDGL KAVGLDFVYK LDEFIKKNSD KIR