P38146

PR
Gene name
YPT10 (YBR264C, YBR1733)
Protein name
GTP-binding protein YPT10
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR264C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-199 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38146

Entry ID Method Resolution Chain Position Source
AF-P38146-F1 Predicted AlphaFoldDB

10 variants for P38146

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-738208 53 S>A No SGRP
s02-738195 57 K>I No SGRP
s02-738190 59 I>V No SGRP
s02-738010 119 I>L No SGRP
s02-737974 131 H>D No SGRP
s02-737958 136 T>I No SGRP
s02-737958 136 T>N No SGRP
s02-737946 140 E>A No SGRP
s02-737899 156 N>D No SGRP
s02-737895 157 F>S No SGRP

No associated diseases with P38146

1 regional properties for P38146

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 3 - 164 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
  • Vesicle
  • Colocalizes with CCZ1 to vesicular structures near the vacuole
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endosome A vacuole to which materials ingested by endocytosis are delivered.
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
guanyl nucleotide binding Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate.

2 GO annotations of biological process

Name Definition
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20339 RAB5A Ras-related protein Rab-5A Homo sapiens (Human) PR
10 20 30 40 50 60
MEATIKVVLL GDSSVGKTSI VTRLKSGKFL AKHAATIGAA FITKTIEVPS NDSSTEKRIH
70 80 90 100 110 120
MEIWDTAGQE RYKSLVPMYY RDANIALIVF ELGDVSSLQC AKTWFQDLQD RAQGTQVIIV
130 140 150 160 170 180
GNKYDLVCEE HSGEVTIPAE LQGLPYVAVS AKTGYNFDTL NKIIISLVPE SQFKTLSKNN
190
EQGNILEINK KKSGSGCIC