P38122

PR
Gene name
ECM31
Protein name
3-methyl-2-oxobutanoate hydroxymethyltransferase
Names
Extracellular matrix protein 31, Ketopantoate hydroxymethyltransferase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR176W
EC number
2.1.2.11: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38122

Entry ID Method Resolution Chain Position Source
AF-P38122-F1 Predicted AlphaFoldDB

6 variants for P38122

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-583820 36 F>V No SGRP
s02-583833 40 P>L No SGRP
s02-583907 65 V>I No SGRP
s02-583979 89 Y>H No SGRP
s02-584088 125 D>G No SGRP
s02-584300 196 E>Q No SGRP

No associated diseases with P38122

1 regional properties for P38122

Type Name Position InterPro Accession
domain Luciferase-like domain 4 - 326 IPR011251

Functions

Description
EC Number 2.1.2.11 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
3-methyl-2-oxobutanoate hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIMKRQLCT SSKRFFSTAK NVVKYNTIQD IRNKYFTGTP LSMCTAYDFI TATWVNKANC
70 80 90 100 110 120
DLLLVGDSLA MTSLGYDSTI TLSLNEFKYH VASVCRAEGS SMVVVDMPFG TFESGISDGL
130 140 150 160 170 180
KNAIDIMKLD SKVTSVKVEV GSYTKDKYAM KFIEELCSRG IPVMAHIGLT PQKVHSLGGY
190 200 210 220 230 240
KVQGSKSLLQ MQELYETAMQ LQKIGCWSIL IECVPHKMAQ FITSKLSVPT IGIGAGNGTS
250 260 270 280 290 300
GQVLVISDLL GMQGDSVPKF VKQAVNMTDI ATQGLKEYIA SVEDRTFPER GTHTFKVKED
310
LWNEFLSSIN EK