P38054

PR
Gene name
cusA (ybdE, b0575, JW0564)
Protein name
Cation efflux system protein CusA
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0575
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

181-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

16 structures for P38054

Entry ID Method Resolution Chain Position Source
3K07 X-ray 352 A A 1-1047 PDB
3K0I X-ray 412 A A 1-1047 PDB
3KSO X-ray 437 A A 1-1047 PDB
3KSS X-ray 388 A A 1-1047 PDB
3NE5 X-ray 290 A A 2-1047 PDB
3T51 X-ray 390 A A 1-1047 PDB
3T53 X-ray 337 A A 1-1047 PDB
3T56 X-ray 342 A A 1-1047 PDB
4DNR X-ray 368 A A 1-1047 PDB
4DNT X-ray 310 A A 1-1047 PDB
4DOP X-ray 420 A A 1-1047 PDB
7KF5 EM 320 A A/B/C 1-1047 PDB
7KF6 EM 340 A A/B/C 1-1047 PDB
7KF7 EM 280 A A/B/C 1-1047 PDB
7KF8 EM 300 A A/B/C 1-1047 PDB
AF-P38054-F1 Predicted AlphaFoldDB

No variants for P38054

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P38054

No associated diseases with P38054

No regional properties for P38054

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P38054

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
silver ion transmembrane transporter activity Enables the transfer of silver (Ag) ions from one side of a membrane to the other.
xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

7 GO annotations of biological process

Name Definition
copper ion export The directed movement of copper ions out of a cell or organelle.
copper ion transmembrane transport The directed movement of copper cation across a membrane.
response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
response to silver ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
silver ion transmembrane transport The directed movement of silver ion across a membrane.
silver ion transport The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIEWIIRRSV ANRFLVLMGA LFLSIWGTWT IINTPVDALP DLSDVQVIIK TSYPGQAPQI
70 80 90 100 110 120
VENQVTYPLT TTMLSVPGAK TVRGFSQFGD SYVYVIFEDG TDPYWARSRV LEYLNQVQGK
130 140 150 160 170 180
LPAGVSAELG PDATGVGWIY EYALVDRSGK HDLADLRSLQ DWFLKYELKT IPDVAEVASV
190 200 210 220 230 240
GGVVKEYQVV IDPQRLAQYG ISLAEVKSAL DASNQEAGGS SIELAEAEYM VRASGYLQTL
250 260 270 280 290 300
DDFNHIVLKA SENGVPVYLR DVAKVQIGPE MRRGIAELNG EGEVAGGVVI LRSGKNAREV
310 320 330 340 350 360
IAAVKDKLET LKSSLPEGVE IVTTYDRSQL IDRAIDNLSG KLLEEFIVVA VVCALFLWHV
370 380 390 400 410 420
RSALVAIISL PLGLCIAFIV MHFQGLNANI MSLGGIAIAV GAMVDAAIVM IENAHKRLEE
430 440 450 460 470 480
WQHQHPDATL DNKTRWQVIT DASVEVGPAL FISLLIITLS FIPIFTLEGQ EGRLFGPLAF
490 500 510 520 530 540
TKTYAMAGAA LLAIVVIPIL MGYWIRGKIP PESSNPLNRF LIRVYHPLLL KVLHWPKTTL
550 560 570 580 590 600
LVAALSVLTV LWPLNKVGGE FLPQINEGDL LYMPSTLPGI SAAEAASMLQ KTDKLIMSVP
610 620 630 640 650 660
EVARVFGKTG KAETATDSAP LEMVETTIQL KPQEQWRPGM TMDKIIEELD NTVRLPGLAN
670 680 690 700 710 720
LWVPPIRNRI DMLSTGIKSP IGIKVSGTVL ADIDAMAEQI EEVARTVPGV ASALAERLEG
730 740 750 760 770 780
GRYINVEINR EKAARYGMTV ADVQLFVTSA VGGAMVGETV EGIARYPINL RYPQSWRDSP
790 800 810 820 830 840
QALRQLPILT PMKQQITLAD VADIKVSTGP SMLKTENARP TSWIYIDARD RDMVSVVHDL
850 860 870 880 890 900
QKAIAEKVQL KPGTSVAFSG QFELLERANH KLKLMVPMTL MIIFVLLYLA FRRVGEALLI
910 920 930 940 950 960
ISSVPFALVG GIWLLWWMGF HLSVATGTGF IALAGVAAEF GVVMLMYLRH AIEAVPSLNN
970 980 990 1000 1010 1020
PQTFSEQKLD EALYHGAVLR VRPKAMTVAV IIAGLLPILW GTGAGSEVMS RIAAPMIGGM
1030 1040
ITAPLLSLFI IPAAYKLMWL HRHRVRK