P37971

PR
Gene name
sigF (rpoX, SCO4035, 2SCD60.01c)
Protein name
RNA polymerase sigma-F factor
Names
Species
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
KEGG Pathway
sco:SCO4035
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P37971

Entry ID Method Resolution Chain Position Source
AF-P37971-F1 Predicted AlphaFoldDB

No variants for P37971

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37971

No associated diseases with P37971

11 regional properties for P37971

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 178 - 191 IPR000943-1
domain RNA polymerase sigma-70 202 - 210 IPR000943-2
domain RNA polymerase sigma-70 326 - 338 IPR000943-3
domain RNA polymerase sigma-70 347 - 373 IPR000943-4
domain RNA polymerase sigma factor 70, region 1.1 24 - 101 IPR007127
domain RNA polymerase sigma-70 region 3 233 - 309 IPR007624
domain RNA polymerase sigma-70 region 2 154 - 223 IPR007627
domain RNA polymerase sigma-70 region 4 322 - 375 IPR007630
domain RNA polymerase sigma-70 region 1.2 113 - 145 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 150 - 386 IPR012760
domain RNA polymerase sigma-70 like domain 152 - 375 IPR014284

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

2 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPASTAPQAP PAPPAQAQAQ APAQAQEAPA PQRSRGADTR ALTQVLFGEL KGLAPGTPEH
70 80 90 100 110 120
DRVRAALIEA NLPLVRYAAA RFRSRNEPME DVVQVGTIGL INAIDRFDPE RGVQFPTFAM
130 140 150 160 170 180
PTVVGEIKRY FRDNVRTVHV PRRLHELWVQ VNSATEDLTT AFGRSPTTAE IAERLRITEE
190 200 210 220 230 240
EVLSCIEAGR SYHATSLEAA QEGDGLPGLL DRLGYEDPAL DGVEHRDLVR HLLVQLPERE
250 260 270 280
QRILLLRYYS NLTQSQISAE LGVSQMHVSR LLARSFQRLR SANRIDA