P37896

PR
Gene name
pepN
Protein name
Aminopeptidase N
Names
Alanine aminopeptidase, Lysyl aminopeptidase, Lys-AP
Species
Lactobacillus delbrueckii subsp lactis
KEGG Pathway
EC number
3.4.11.2: Aminopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

316-386 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P37896

Entry ID Method Resolution Chain Position Source
AF-P37896-F1 Predicted AlphaFoldDB

No variants for P37896

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37896

No associated diseases with P37896

3 regional properties for P37896

Type Name Position InterPro Accession
domain Peptidase M1, membrane alanine aminopeptidase 216 - 434 IPR014782
domain ERAP1-like C-terminal domain 507 - 813 IPR024571
domain Aminopeptidase N-like, N-terminal domain 11 - 180 IPR045357

Functions

Description
EC Number 3.4.11.2 Aminopeptidases
Subcellular Localization
  • Cytoplasm
  • It may be secreted through an unknown mechanism
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVKRFYETF HPDHYDLYID VDRAARSFSG TSTIHGEIQE ETVLVHQKYM TISKVTVDGK
70 80 90 100 110 120
EVPFTFGDDF EGIKIEAGKT GEAVIAIDYS APLTDTMMGI YPSYYQVDGV KKELIGTQFE
130 140 150 160 170 180
TTFAREAFPC VDEPEAKATF SLALKFDEHE GETVLANMPE DRVENGVHYF KETVRMSSYL
190 200 210 220 230 240
VAFAFGEMRS LTTHTKSGVL IGVYSTQAHT EKELTFSLDI AKRAIEFYED FYQTPYPLPQ
250 260 270 280 290 300
SLQLALPDFS AGAMENWGLV TYREAYLLLD PDNTTLEMKK LVATVVTHEL AHQWFGDLVT
310 320 330 340 350 360
MEWWDNLWLN ESFANMMEYL SVDHLEPNWH IWEMFQTSEA AAALTRDATD GVQSVHVEVN
370 380 390 400 410 420
DPAEIDALFD GAIVYAKGSR MLVMVRSLLG DEALRKGLKR YFDKHKFGNA AGDDLWDALS
430 440 450 460 470 480
TATDLNIGEI MHTWLDQPGY PVVNAFVEDG HLKLTQKQFF IGEGKEVGRK WEIPLNANFK
490 500 510 520 530 540
APKIMSDVEL DLGDYQALRA EAGHALRLNV GNNSHFIVKY DQTLMDDIMK EAKDLDPVSQ
550 560 570 580 590 600
LQLLQDLRLL AEGKQASYAD VVPVLELFKN SESHIVNDAL YTTADKLRQF APAGSEADKN
610 620 630 640 650 660
LRALYNDLSK DQVARLGWLP KAGESDEDIQ TRPYVLSASL YGRNADSEKQ AHEIYVEYAD
670 680 690 700 710 720
KLAELSADIR PYVLINEVEN YGSSELTDKL IGLYQATSDP SFKMDLEAAI VKSKDEGELK
730 740 750 760 770 780
KIVSWFKNAE IVKPQDLRGW FSGVLSNPAG EQLAWDWIRD EWAWLEKTVG GDMEFATFIT
790 800 810 820 830 840
VISRVFKTKE RYDEYNAFFT DKESNMLLNR EIKMDRKVIA NRVDLIASEQ ADVNAAVAAA
LQK