P37870

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU01070
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

197-277 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P37870

Entry ID Method Resolution Chain Position Source
2LY7 NMR - A 784-923 PDB
6WVJ EM 336 A C 1-1193 PDB
6WVK EM 336 A C 1-1193 PDB
6ZCA EM 420 A X 1-1193 PDB
6ZFB EM 390 A X/x 1-1193 PDB
7CKQ EM 440 A C 1-1193 PDB
7F75 EM 420 A C 1-1193 PDB
AF-P37870-F1 Predicted AlphaFoldDB

1 variants for P37870

Variant ID(s) Position Change Description Diseaes Association Provenance
482 H>Y rfm2103; rifampicin resistant [UniProt] No

No associated diseases with P37870

8 regional properties for P37870

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 676 - 1069 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 922 - 934 IPR007121
domain RNA polymerase Rpb2, domain 7 1071 - 1145 IPR007641
domain RNA polymerase Rpb2, domain 2 140 - 290 IPR007642-1
domain RNA polymerase Rpb2, domain 2 371 - 410 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 28 - 454 IPR007644
domain RNA polymerase Rpb2, domain 3 469 - 537 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 547 - 614 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

2 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTGQLVQYGR HRQRRSYARI SEVLELPNLI EIQTSSYQWF LDEGLREMFQ DISPIEDFTG
70 80 90 100 110 120
NLSLEFIDYS LGEPKYPVEE SKERDVTYSA PLRVKVRLIN KETGEVKDQD VFMGDFPIMT
130 140 150 160 170 180
DTGTFIINGA ERVIVSQLVR SPSVYFSGKV DKNGKKGFTA TVIPNRGAWL EYETDAKDVV
190 200 210 220 230 240
YVRIDRTRKL PVTVLLRALG FGSDQEILDL IGENEYLRNT LDKDNTENSD KALLEIYERL
250 260 270 280 290 300
RPGEPPTVEN AKSLLDSRFF DPKRYDLANV GRYKINKKLH IKNRLFNQRL AETLVDPETG
310 320 330 340 350 360
EILAEKGQIL DRRTLDKVLP YLENGIGFRK LYPNGGVVED EVTLQSIKIF APTDQEGEQV
370 380 390 400 410 420
INVIGNAYIE EEIKNITPAD IISSISYFFN LLHGVGDTDD IDHLGNRRLR SVGELLQNQF
430 440 450 460 470 480
RIGLSRMERV VRERMSIQDT NTITPQQLIN IRPVIASIKE FFGSSQLSQF MDQTNPLAEL
490 500 510 520 530 540
THKRRLSALG PGGLTRERAG MEVRDVHYSH YGRMCPIETP EGPNIGLINS LSSYAKVNRF
550 560 570 580 590 600
GFIETPYRRV DPETGKVTGR IDYLTADEED NYVVAQANAR LDDEGAFIDD SIVARFRGEN
610 620 630 640 650 660
TVVSRNRVDY MDVSPKQVVS AATACIPFLE NDDSNRALMG ANMQRQAVPL MQPEAPFVGT
670 680 690 700 710 720
GMEYVSGKDS GAAVICKHPG IVERVEAKNV WVRRYEEVDG QKVKGNLDKY SLLKFVRSNQ
730 740 750 760 770 780
GTCYNQRPIV SVGDEVVKGE ILADGPSMEL GELALGRNVM VGFMTWDGYN YEDAIIMSER
790 800 810 820 830 840
LVKDDVYTSI HIEEYESEAR DTKLGPEEIT RDIPNVGEDA LRNLDDRGII RIGAEVKDGD
850 860 870 880 890 900
LLVGKVTPKG VTELTAEERL LHAIFGEKAR EVRDTSLRVP HGGGGIIHDV KVFNREDGDE
910 920 930 940 950 960
LPPGVNQLVR VYIVQKRKIS EGDKMAGRHG NKGVISKILP EEDMPYLPDG TPIDIMLNPL
970 980 990 1000 1010 1020
GVPSRMNIGQ VLELHMGMAA RYLGIHIASP VFDGAREEDV WETLEEAGMS RDAKTVLYDG
1030 1040 1050 1060 1070 1080
RTGEPFDNRV SVGIMYMIKL AHMVDDKLHA RSTGPYSLVT QQPLGGKAQF GGQRFGEMEV
1090 1100 1110 1120 1130 1140
WALEAYGAAY TLQEILTVKS DDVVGRVKTY EAIVKGDNVP EPGVPESFKV LIKELQSLGM
1150 1160 1170 1180 1190
DVKILSGDEE EIEMRDLEDE EDAKQADGLA LSGDEEPEET ASADVERDVV TKE