P37634

PR
Gene name
rlmJ
Protein name
Ribosomal RNA large subunit methyltransferase J
Names
23S rRNA (adenine(2030)-N6)-methyltransferase, 23S rRNA m6A2030 methyltransferase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3499
EC number
2.1.1.266: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for P37634

Entry ID Method Resolution Chain Position Source
4BLU X-ray 185 A A/B 1-280 PDB
4BLV X-ray 200 A A/B 1-280 PDB
4BLW X-ray 195 A A/B 1-280 PDB
6QDX X-ray 210 A A/B/C/D 1-280 PDB
6QE0 X-ray 139 A A 1-280 PDB
6QE5 X-ray 161 A A/B 1-280 PDB
7P8Q X-ray 229 A A 1-280 PDB
7P9I X-ray 159 A A/B 1-280 PDB
7P9O X-ray 210 A A 1-280 PDB
AF-P37634-F1 Predicted AlphaFoldDB

No variants for P37634

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37634

No associated diseases with P37634

1 regional properties for P37634

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 241 - 247 IPR002052

Functions

Description
EC Number 2.1.1.266 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
23S rRNA (adenine(2030)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine.

2 GO annotations of biological process

Name Definition
carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSYRHSFHA GNHADVLKHT VQSLIIESLK EKDKPFLYLD THAGAGRYQL GSEHAERTGE
70 80 90 100 110 120
YLEGIARIWQ QDDLPAELEA YINVVKHFNR SGQLRYYPGS PLIARLLLRE QDSLQLTELH
130 140 150 160 170 180
PSDYPLLRSE FQKDSRARVE KADGFQQLKA KLPPVSRRGL ILIDPPYEMK TDYQAVVSGI
190 200 210 220 230 240
AEGYKRFATG IYALWYPVVL RQQIKRMIHD LEATGIRKIL QIELAVLPDS DRRGMTASGM
250 260 270
IVINPPWKLE QQMNNVLPWL HSKLVPAGTG HATVSWIVPE