P37610

PR
Gene name
tauD (ssiD, yaiG, b0368, JW0360)
Protein name
Alpha-ketoglutarate-dependent taurine dioxygenase
Names
2-aminoethanesulfonate dioxygenase, Sulfate starvation-induced protein 3, SSI3
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0368
EC number
1.14.11.17: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P37610

Entry ID Method Resolution Chain Position Source
1GQW X-ray 300 A A/B 2-283 PDB
1GY9 X-ray 250 A A/B 2-283 PDB
1OS7 X-ray 250 A A/B/C/D 1-283 PDB
1OTJ X-ray 190 A A/B/C/D 1-283 PDB
6EDH X-ray 173 A A/B 1-283 PDB
AF-P37610-F1 Predicted AlphaFoldDB

No variants for P37610

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37610

No associated diseases with P37610

1 regional properties for P37610

Type Name Position InterPro Accession
domain TauD/TfdA-like domain 7 - 272 IPR003819

Functions

Description
EC Number 1.14.11.17 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
taurine dioxygenase complex A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD.

4 GO annotations of molecular function

Name Definition
2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
ferrous iron binding Binding to a ferrous iron ion, Fe(II).
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
taurine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite.

2 GO annotations of biological process

Name Definition
sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
taurine catabolic process The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSERLSITPL GPYIGAQISG ADLTRPLSDN QFEQLYHAVL RHQVVFLRDQ AITPQQQRAL
70 80 90 100 110 120
AQRFGELHIH PVYPHAEGVD EIIVLDTHND NPPDNDNWHT DVTFIETPPA GAILAAKELP
130 140 150 160 170 180
STGGDTLWTS GIAAYEALSV PFRQLLSGLR AEHDFRKSFP EYKYRKTEEE HQRWREAVAK
190 200 210 220 230 240
NPPLLHPVVR THPVSGKQAL FVNEGFTTRI VDVSEKESEA LLSFLFAHIT KPEFQVRWRW
250 260 270 280
QPNDIAIWDN RVTQHYANAD YLPQRRIMHR ATILGDKPFY RAG