P37582
Gene name |
glnR |
Protein name |
HTH-type transcriptional regulator GlnR |
Names |
|
Species |
Bacillus subtilis (strain 168) |
KEGG Pathway |
bsu:BSU17450 |
EC number |
|
Protein Class |
REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR (PTHR30204) |
Descriptions
GlnR is a repressor that regulates gene expression in response to changes in nitrogen availability. The C-terminal autoinhibitory region was identified by sequence similarity with GlnR, which impedes the dimerization of GlnR and consequently prevents the binding of GlnR N-terminal domain to DNA.
Autoinhibitory domains (AIDs)
Target domain |
12-92 (DNA-binding domain) |
Relief mechanism |
Partner binding |
Assay |
Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P37582
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4R4E | X-ray | 257 A | A/B | 1-84 | PDB |
| 7TFC | EM | 196 A | D/E/J/K/L/M/U/V/W/X/Y/Z/a/b | 124-133 | PDB |
| AF-P37582-F1 | Predicted | AlphaFoldDB |
1 variants for P37582
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 96 | M>V | strain: PCI 219 [UniProt] | No |
No associated diseases with P37582
1 regional properties for P37582
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MerR-type HTH domain | 11 - 80 | IPR000551 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR30204 | REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR |
| PANTHER Subfamily | PTHR30204:SF65 | HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA |
| PANTHER Protein Class |
helix-turn-helix transcription factor
winged helix/forkhead transcription factor |
|
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| identical protein binding | Binding to an identical protein or proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDNIRRSMP | LFPIGIVMQL | TELSARQIRY | YEENGLIFPA | RSEGNRRLFS | FHDVDKLLEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHLIEQGVNM | AGIKQILAKA | EAEPEQKQNE | KTKKPMKHDL | SDDELRQLLK | NELMQAGRFQ |
| 130 | |||||
| RGNTFRQGDM | SRFFH |