P37321

PR
Gene name
per1
Protein name
Extended-spectrum beta-lactamase PER-1
Names
Species
Pseudomonas aeruginosa
KEGG Pathway
ag:CAA79968
EC number
3.5.2.6: In cyclic amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P37321

Entry ID Method Resolution Chain Position Source
1E25 X-ray 190 A A 27-308 PDB
AF-P37321-F1 Predicted AlphaFoldDB

No variants for P37321

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37321

No associated diseases with P37321

2 regional properties for P37321

Type Name Position InterPro Accession
active_site Beta-lactamase, class-A active site 67 - 82 IPR023650
domain Beta-lactamase class A, catalytic domain 54 - 273 IPR045155

Functions

Description
EC Number 3.5.2.6 In cyclic amides
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
beta-lactamase activity Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid.

2 GO annotations of biological process

Name Definition
beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNVIIKAVVT ASTLLMVSFS SFETSAQSPL LKEQIESIVI GKKATVGVAV WGPDDLEPLL
70 80 90 100 110 120
INPFEKFPMQ SVFKLHLAML VLHQVDQGKL DLNQTVIVNR AKVLQNTWAP IMKAYQGDEF
130 140 150 160 170 180
SVPVQQLLQY SVSHSDNVAC DLLFELVGGP AALHDYIQSM GIKETAVVAN EAQMHADDQV
190 200 210 220 230 240
QYQNWTSMKG AAEILKKFEQ KTQLSETSQA LLWKWMVETT TGPERLKGLL PAGTVVAHKT
250 260 270 280 290 300
GTSGIKAGKT AATNDLGIIL LPDGRPLLVA VFVKDSAESS RTNEAIIAQV AQTAYQFELK
KLSALSPN