P37251

PR
Gene name
ilvB (BSU28310)
Protein name
Acetolactate synthase large subunit
Names
AHAS, Acetohydroxy-acid synthase large subunit, ALS, Vegetative protein 105, VEG105
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU28310
EC number
2.2.1.6: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P37251

Entry ID Method Resolution Chain Position Source
AF-P37251-F1 Predicted AlphaFoldDB

No variants for P37251

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37251

No associated diseases with P37251

4 regional properties for P37251

Type Name Position InterPro Accession
domain Thiamine pyrophosphate enzyme, TPP-binding 400 - 548 IPR011766
domain Thiamine pyrophosphate enzyme, central domain 207 - 342 IPR012000
domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 18 - 180 IPR012001
domain Acetolactate synthase large subunit, TPP binding domain 378 - 563 IPR039368

Functions

Description
EC Number 2.2.1.6 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
acetolactate synthase complex A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.

4 GO annotations of molecular function

Name Definition
acetolactate synthase activity Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

2 GO annotations of biological process

Name Definition
isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGTNVQVDSA SAECTQTMSG ALMLIESLKK EKVEMIFGYP GGAVLPIYDK LYNSGLVHIL
70 80 90 100 110 120
PRHEQGAIHA AEGYARVSGK PGVVIATSGP GATNLVTGLA DAMIDSLPLV VFTGQVATSV
130 140 150 160 170 180
IGSDAFQEAD ILGITMPVTK HSYQVRQPED LPRIIKEAFH IATTGRPGPV LIDIPKDVAT
190 200 210 220 230 240
IEGEFSYDHE MNLPGYQPTT EPNYLQIRKL VEAVSSAKKP VILAGAGVLH GKASEELKNY
250 260 270 280 290 300
AEQQQIPVAH TLLGLGGFPA DHPLFLGMAG MHGTYTANMA LHECDLLISI GARFDDRVTG
310 320 330 340 350 360
NLKHFARNAK IAHIDIDPAE IGKIMKTQIP VVGDSKIVLQ ELIKQDGKQS DSSEWKKQLA
370 380 390 400 410 420
EWKEEYPLWY VDNEEEGFKP QKLIEYIHQF TKGEAIVATD VGQHQMWSAQ FYPFQKADKW
430 440 450 460 470 480
VTSGGLGTMG FGLPAAIGAQ LAEKDATVVA VVGDGGFQMT LQELDVIREL NLPVKVVILN
490 500 510 520 530 540
NACLGMVRQW QEIFYEERYS ESKFASQPDF VKLSEAYGIK GIRISSEAEA KEKLEEALTS
550 560 570
REPVVIDVRV ASEEKVFPMV APGKGLHEMV GVKP