P37142

PR
Gene name
Protein name
Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic
Names
AK-HD, AK-HSDH
Species
Daucus carota (Wild carrot)
KEGG Pathway
EC number
1.1.1.3: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P37142

Entry ID Method Resolution Chain Position Source
AF-P37142-F1 Predicted AlphaFoldDB

No variants for P37142

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37142

No associated diseases with P37142

10 regional properties for P37142

Type Name Position InterPro Accession
domain Aspartate/glutamate/uridylate kinase 92 - 374 IPR001048
domain Aspartate kinase 91 - 556 IPR001341
domain Homoserine dehydrogenase, catalytic 713 - 911 IPR001342
domain ACT domain 417 - 489 IPR002912-1
domain ACT domain 498 - 575 IPR002912-2
domain Aspartate/homoserine dehydrogenase, NAD-binding 569 - 705 IPR005106
conserved_site Aspartate kinase, conserved site 94 - 102 IPR018042
conserved_site Homoserine dehydrogenase, conserved site 759 - 781 IPR019811
domain CASTOR, ACT domain 491 - 554 IPR027795
domain Bifunctional aspartokinase/homoserine dehydrogenase, N-terminal catalytic domain 92 - 386 IPR041743

Functions

Description
EC Number 1.1.1.3 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

4 GO annotations of molecular function

Name Definition
aspartate kinase activity Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
homoserine dehydrogenase activity Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

4 GO annotations of biological process

Name Definition
lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
SLSSAISPSS YAAIAAAYSA RTPIFNKKKT AAVLSPLSLF HQSPSLSKTG IFLHRGRKES
70 80 90 100 110 120
SSKFYIAASV TTAVPSLDDS VEKVHLPRGA MWSIHKFGGT CVGSSERIRN VAEIVVEDDS
130 140 150 160 170 180
ERKLVVVSAM SKVTDMMYDL IYKAQSRDDS YESALDAVME KHKLTAFDLL DEDDLARFLT
190 200 210 220 230 240
RLQHDVITLK AMLRAIYIAG HATESFSDFV VGHGELWSAQ LLSFVIRKNG GDCNWMDTRD
250 260 270 280 290 300
VLVVNPAGSN QVDPDYLESE KRLEKWFSSN QCQTIVATGF IASTPQNIPT TLKRDGSDFS
310 320 330 340 350 360
AAIMGALLRA GQVTIWTDVN GVYSADPRKV SEAVVLKTLS YQEAWEMSYF GANVLHPRTI
370 380 390 400 410 420
NPVMRYDIPI VIRNIFNLSA PGTMICRESV GETEDGLKLE SHVKGFATID NLALINVEGT
430 440 450 460 470 480
GMAGVPGTAT AIFGAVKDVG ANVIMISQAS SEHSICFAVP ESEVKAVAKA LEARFRQALD
490 500 510 520 530 540
AGRLSQVANN PNCSILATVG QKMASTPGVS ATLFNALAKA NINVRAIAQG CTEYNITVVL
550 560 570 580 590 600
SREDCVRALK AVHSRFYLSR TTIAVGIVGP GLIGATLLDQ LRDQAAILKE NSKIDLRVMG
610 620 630 640 650 660
ITGSRTMLLS ETGIDLSRWR EVQKEKGQTA GLEKFVQHVR GNHFIPSTVI VDCTADSEVA
670 680 690 700 710 720
SHYHDWLCRG IHVITPNKKA NSGPLDQYLK LRALQRRSYT HYFYEATVVA GLPIITTLQG
730 740 750 760 770 780
LLETGDKILR IEGIFSGTLS YIFNNFKSTT PFSEVVSEAK AAGYTEPDPR DDLAGTDVAR
790 800 810 820 830 840
KVIILARGSG LKLELSDIPV QSLVPEPLRG IASAEEFLLQ LPQFDSDMTR KREDAENAGE
850 860 870 880 890 900
VLRYVGVVDA VNQKGVVELK RYKKEHPFAQ LSGSDNINAF TTERYNKQPP IIRGPGAGAE
910 920
VTAGGVFSDI LRLASYLGAP S