P36672

PR
Gene name
treB (b4240, JW4199)
Protein name
PTS system trehalose-specific EIIBC component
Names
EIIBC-Tre, EII-Tre
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b4240
EC number
2.7.1.201: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36672

Entry ID Method Resolution Chain Position Source
AF-P36672-F1 Predicted AlphaFoldDB

No variants for P36672

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P36672

No associated diseases with P36672

6 regional properties for P36672

Type Name Position InterPro Accession
domain Phosphotransferase system, IIB component, type 1 7 - 112 IPR001996
domain Phosphotransferase system, EIIC 114 - 405 IPR003352
domain Phosphotransferase system, maltose/glucose-specific subfamily IIC component 164 - 448 IPR004719
domain Phosphotransferase system, trehalose-specific IIBC component 8 - 461 IPR011296
domain Phosphotransferase system, EIIC component, type 1 109 - 473 IPR013013
conserved_site Phosphotransferase system EIIB, cysteine phosphorylation site 13 - 84 IPR018113

Functions

Description
EC Number 2.7.1.201 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
protein-phosphocysteine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
protein-phosphocysteine-trehalose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in).
trehalose transmembrane transporter activity Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens.

3 GO annotations of biological process

Name Definition
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
trehalose transport The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMSKINQTDI DRLIELVGGR GNIATVSHCI TRLRFVLNQP ANARPKEIEQ LPMVKGCFTN
70 80 90 100 110 120
AGQFQVVIGT NVGDYYQALI ASTGQAQVDK EQVKKAARHN MKWHEQLISH FAVIFFPLLP
130 140 150 160 170 180
ALISGGLILG FRNVIGDLPM SNGQTLAQMY PSLQTIYDFL WLIGEAIFFY LPVGICWSAV
190 200 210 220 230 240
KKMGGTPILG IVLGVTLVSP QLMNAYLLGQ QLPEVWDFGM FSIAKVGYQA QVIPALLAGL
250 260 270 280 290 300
ALGVIETRLK RIVPDYLYLV VVPVCSLILA VFLAHALIGP FGRMIGDGVA FAVRHLMTGS
310 320 330 340 350 360
FAPIGAALFG FLYAPLVITG VHQTTLAIDL QMIQSMGGTP VWPLIALSNI AQGSAVIGII
370 380 390 400 410 420
ISSRKHNERE ISVPAAISAW LGVTEPAMYG INLKYRFPML CAMIGSGLAG LLCGLNGVMA
430 440 450 460 470
NGIGVGGLPG ILSIQPSYWQ VFALAMAIAI IIPIVLTSFI YQRKYRLGTL DIV