P36629
Gene name |
prp2 (mis11, SPBC146.07) |
Protein name |
Splicing factor U2AF 59 kDa subunit |
Names |
U2 auxiliary factor 59 kDa subunit, U2AF59, U2 snRNP auxiliary factor large subunit |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC146.07 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P36629
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4YH8 | X-ray | 170 A | B | 93-161 | PDB |
| 7C06 | X-ray | 302 A | B/E/H/K/N/Q/T/W/Z | 93-161 | PDB |
| 7C07 | X-ray | 320 A | B/E/H/K/N/Q/T/W/Z | 93-161 | PDB |
| 7C08 | X-ray | 335 A | B/E/H/K/N/Q/T/W/Z | 93-161 | PDB |
| AF-P36629-F1 | Predicted | AlphaFoldDB |
No variants for P36629
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P36629 | |||||
No associated diseases with P36629
2 regional properties for P36629
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 310 - 388 | IPR000504-1 |
| domain | RNA recognition motif domain | 418 - 509 | IPR000504-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| commitment complex | A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U2-type prespliceosome | A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. |
| U2AF complex | A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| poly-pyrimidine tract binding | Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
| pre-mRNA 3'-splice site binding | Binding to a pre-mRNA 3' splice site sequence. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA branch site recognition | Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. |
| mRNA cis splicing, via spliceosome | The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. |
| spliceosomal complex assembly | The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLSSRLSSG | SSRIPKRHRD | YRDEEPRRER | GSGGIGREDP | RGHYGSERPR | RRRRDESDFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RHRESRERSY | REDERPRRER | RYDDYEPRSL | RYSSVGRSRS | PPPSRERSVR | SIEQELEQLR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVTPINQWKR | KRSLWDIKPP | GYELVTADQA | KMSGVFPLPG | APRAAVTDPE | KLLEFARSAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GSIIAPPPPL | QPGASRQARR | LVVTGIPNEF | VEDAFVSFIE | DLFISTTYHK | PETKHFSSVN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VCKEENFAIL | EVATPEDATF | LWGLQSESYS | NDVFLKFQRI | QNYIVPQITP | EVSQKRSDDY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AKNDVLDSKD | KIYISNLPLN | LGEDQVVELL | KPFGDLLSFQ | LIKNIADGSS | KGFCFCEFKN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSDAEVAISG | LDGKDTYGNK | LHAQFACVGL | NQAMIDKSNG | MAILTELAKA | SSQSIPTRVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLHNLITGDE | IMDVQEYEDI | YESVKTQFSN | YGPLIDIKIP | RSIGTRNSGL | GTGKVFVRYS |
| 490 | 500 | 510 | |||
| DIRSAEVAME | EMKGCKFNDR | TIVIAFYGED | CYKANAW |