P36598

PR
Gene name
thi1 (ntf1, SPAC1486.10, SPAC6G10.01)
Protein name
Thiamine repressible genes regulatory protein thi1
Names
Transcription factor ntf1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1486.10
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36598

Entry ID Method Resolution Chain Position Source
AF-P36598-F1 Predicted AlphaFoldDB

11 variants for P36598

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3212219_C_G 81 L>V No Jeffares_SNPs
I_3212319_A_G 114 K>R No Jeffares_SNPs
I_3212886_C_T 303 A>V No Jeffares_SNPs
I_3212978_G_A 334 V>I No Jeffares_SNPs
I_3213287_A_G 437 I>V No Jeffares_SNPs
I_3213327_T_C 450 V>A No Jeffares_SNPs
I_3213719_G_A 581 V>I No Jeffares_SNPs
I_3213771_C_T 598 S>F No Jeffares_SNPs
I_3213908_A_G 644 I>V No Jeffares_SNPs
I_3213978_A_G 667 H>R No Jeffares_SNPs
I_3214169_A_G 731 N>D No Jeffares_SNPs

No associated diseases with P36598

1 regional properties for P36598

Type Name Position InterPro Accession
domain ThiC-associated domain 17 - 72 IPR025747

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of thiamine biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNEEIGFLKN QLFADVKDLE RKKKRRVPPE QRRRVFRACK HCRQKKIKCN GGQPCISCKT
70 80 90 100 110 120
LNIECVYAQK SQNKTLSREY LEELSERQLC LEYIFSRMCP NFNLETKNLI SISKKLSENE
130 140 150 160 170 180
NLPVSKIAEV TNELDTLVRI NDQLSRNHIS GTTEEMQSSS SLIAGEVQPG ISFRDQLKVG
190 200 210 220 230 240
KLEDTLYLGP TTSEAFIERL QNELELESIS EDDLYSKRLS PSVSYSEFDE QLLLHARSLI
250 260 270 280 290 300
PSKAVVEFLI NSFFINVQTN LFVYHPHFFK CRLEIFLAME NQIDAGFLCI LLMVLAFGNQ
310 320 330 340 350 360
YTAEQQEDVS KSNFHASNIG NRLFSAALSI FPLVLLQSDV SAVQSSLLIG LYLQSTIYEK
370 380 390 400 410 420
SSFAYFGLAI KFAVALGLHK NSDDPSLTQN SKELRNRLLW SVFCIDRFVS MTTGRRPSIP
430 440 450 460 470 480
LECISIPYPV ILPDLEIPGS QSIVENMRAV INLAKLTNEI CDSLYWNPSP SFESQVNSVR
490 500 510 520 530 540
RIYARLELWK SDLHSSVVFD ESAVQHPLFR SNAHVQMIYD NAIMLTTRVI MVKKLKDKDL
550 560 570 580 590 600
TAENRRYIQL CVESATRVIN IAHLLLTHKC LSSLSFFGLH VPFASAPILL LSLHYENSQD
610 620 630 640 650 660
IQAVVTKLWQ VLEFLSSRCE FARESLNYLK SFNKQLSRRN APDINNPIAD FQNSFQNWQS
670 680 690 700 710 720
WVGDMSHGDM LSTFKLTGES SNGSNSTPNE AFQPFDQTSS LYNVPGLNKS YVSNQPSLLT
730 740 750 760 770
PETFLPDPVL NLEVDKQWTA PTFLSWTELL GPTNVSEQSS HTAEQTSNLT LEKNG