P36534

PR
Gene name
MRPL40 (YPL173W)
Protein name
54S ribosomal protein L40, mitochondrial
Names
Mitochondrial large ribosomal subunit protein uL24m, YmL40
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL173W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P36534

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A Q 1-297 PDB
5MRC EM 325 A Q 2-297 PDB
5MRE EM 375 A Q 2-297 PDB
5MRF EM 497 A Q 2-297 PDB
AF-P36534-F1 Predicted AlphaFoldDB

2 variants for P36534

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-223629 163 A>V No SGRP
s16-223880 247 V>I No SGRP

No associated diseases with P36534

No regional properties for P36534

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P36534

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGSYQHLSN VGSRVMKRLG NRPKNFLPHS EKFIKKSTPE FMKSDLKEVD EKTSFKSEKE
70 80 90 100 110 120
WKFIPGDRVV VMSGASKGNI AVIKSFDKRT NSFILDENGP TKTVPVPKQF WLEGQTSHMI
130 140 150 160 170 180
TIPVSILGKD LRLVADIDDE KTPGKTRTVA VRDVSFNGSY YDADYKKVMP YRCVKGQPDL
190 200 210 220 230 240
IIPWPKPDPI DVQTNLATDP VIAREQTFWV DSVVRNPIPK KAIPSIRNPH SKYKRGTLTA
250 260 270 280 290
KDIAKLVAPE MPLTEVRKSH LAEKKELAER EVPKLTEEDM EAIGARVFEF LEKQKRE