P36525

PR
Gene name
MRPL24 (MRPL14, YMR193W, YM9646.05)
Protein name
54S ribosomal protein L24, mitochondrial
Names
Mitochondrial large ribosomal subunit protein bL28m, YmL14/YmL24
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR193W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P36525

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A S 1-258 PDB
5MRC EM 325 A S 22-237 PDB
5MRE EM 375 A S 22-237 PDB
5MRF EM 497 A S 22-237 PDB
AF-P36525-F1 Predicted AlphaFoldDB

5 variants for P36525

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-650143 37 N>D No SGRP
s13-650146 38 Y>H No SGRP
s13-650335 101 V>L No SGRP
s13-650712 226 N>K No SGRP
s13-650713 227 Y>H No SGRP

No associated diseases with P36525

No regional properties for P36525

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P36525

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKIFRPFQL TRGFTSSVKN FRQWRLIETR KIAKQPNYQV GDAKPLHMPK ERKKFPDYKY
70 80 90 100 110 120
GESNIFKQSN KGLYGGSFVQ FGNNISESKA KTRKKWLPNV VKKGLWSETL NRKISIKMTA
130 140 150 160 170 180
KVLKTISKEG GIDNYLTKEK SARIKELGPT GWKLRYRVLK RKDEIENPPH KDAPIIEMAG
190 200 210 220 230 240
GKKAKIYYDE IVNGSPRKIS VGRRRLMSFL YPLEKLEYRS VGKDLNYKKF VELFADVPVK
250
DILARLEDHK FDLSTITV