P36420

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Lactobacillus casei
KEGG Pathway
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

816-883 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36420

Entry ID Method Resolution Chain Position Source
AF-P36420-F1 Predicted AlphaFoldDB

No variants for P36420

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P36420

No associated diseases with P36420

5 regional properties for P36420

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 50 - 61 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 22 - 566 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 610 - 756 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 816 - 881 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 566 - 701 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEPVSDETLA PKYDHKAVEE GRYQEWLDED VFKPSGDKKA KPYSIVIPPP NVTGKLHMGH
70 80 90 100 110 120
AWDTTLQDIV IRQKRIEGFD TLWLPGMDHA GIATQAKVEA KLRKEGISRY DLGREKFVQK
130 140 150 160 170 180
VWEWKDEFAK TIHGQWAKMG LSLDYSRERF TLDKGLNQAV RRVFVDLYNQ GLIYRGEYIV
190 200 210 220 230 240
NWDPQARTAL SDIEVIHKDD KGAFYHVKYP FADGSGYIEI ATTRPETMMG DTAVAVHPGD
250 260 270 280 290 300
ERYKDMVGTE LILPLANRKI PIIEDAYVDP EFGTGAVKIT PAHDPNDFQV GNRHDLKRIN
310 320 330 340 350 360
TMNDDGTMNE NAGKYQGMDR FEARKAMVAD LDKAGLLLKV EPIVHSVGHS ERTGVQVEAR
370 380 390 400 410 420
LSTQWFVKMK PLAEAAIKAQ QEPDKKVTFV PERFEHTYLQ WMENIHDWVI SRQLWWGHQI
430 440 450 460 470 480
PAWYNKQTGE TYVGMEAPKD IENWKQDPDV LDTWFSSALW PFSTMGWPNT DAPDYKRYYP
490 500 510 520 530 540
TDTLVTGYDI IPFWVARMIF QGLHFTHQRP FQYTLIHGLM RDEQGRKMSK SLGNGIDPMD
550 560 570 580 590 600
VIEKYGADAL RWFLITGNKP GQDTRFSYKQ VEAAWNFINK IWNISRFVMM NLGDLDTPQQ
610 620 630 640 650 660
PDPSTFDLSD KWLFAQLNET IKQVMDLSAR FEFGEMGRTL YNFTWNVLAD WYVEMSKEVL
670 680 690 700 710 720
YGDDEQAKAA KRVNLAYALD QILRLLHPVM PFVHGKLWLA LPHTGKSIVT ASYPVANTAF
730 740 750 760 770 780
ENADATSAMD AIIALIRGVR GIRKEAGAPL KTKVDILVKL TDPALKPIFE QNFDFIDRFV
790 800 810 820 830 840
NSKAFTVGTD VAEPKMAGSA VITGATIFVP LNELIDLDEE KAKLTKDAKK LEQEIARIDK
850 860 870 880
KLNNQGFLSK APEAVVAEQR TKRSDFEDQL TSTKQRLEQL QRA