P36366

PR
Gene name
FMO2
Protein name
Dimethylaniline monooxygenase [N-oxide-forming] 2
Names
Dimethylaniline oxidase 2, FMO 1B1, Pulmonary flavin-containing monooxygenase 2, FMO 2
Species
Cavia porcellus (Guinea pig)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

465-535 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36366

Entry ID Method Resolution Chain Position Source
AF-P36366-F1 Predicted AlphaFoldDB

2 variants for P36366

Variant ID(s) Position Change Description Diseaes Association Provenance
522 V>L B form [UniProt] No
530 S>F B form [UniProt] No

No associated diseases with P36366

No regional properties for P36366

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P36366

Functions

Description
EC Number
Subcellular Localization
  • Microsome membrane ; Single-pass membrane protein
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
N,N-dimethylaniline monooxygenase activity Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

1 GO annotations of biological process

Name Definition
NADPH oxidation A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGL WRFKENVEDG RASIYKSVIT
70 80 90 100 110 120
NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRLFAKKFDL LKYIQFQTTV LTVKKHPDFS
130 140 150 160 170 180
SSGQWEVVTQ SDGKEQSAVF DAVMVCSGHH ILPHIPLKSF PGIERFKGQY FHSRQYKHPA
190 200 210 220 230 240
GFEGKRILVI GIGNSASDIA SELSKNAAQV FISTRNGSWV MSRISEDGYP WDMVFHTRFK
250 260 270 280 290 300
SMLRNILPRT VSKWMMEQQL NRWFNHANYS LEPKNKYLMK EPILNDDLPS RILYGAVKVK
310 320 330 340 350 360
SRVTQLTETS ALFEDGTVEE DIDVIVFATG YTFSFPFLEE SLVKIEHNMV SLYKYMFPPQ
370 380 390 400 410 420
LEKPTLTCMG LIQPLGSIFP TVELQARWAT RVFKGLCHLP SEKTMMEDII KRNEKRIDLF
430 440 450 460 470 480
GESQSQIVQT NYVDYLDELA LEIGAKPDLI SFLLKDPELA VKLCFGPCNS YQYRLVGPGQ
490 500 510 520 530
WEGARRAILT QKQRILKPLK TRSVKAAPNL SASFLMKILA LVAVFVAFFS QLYGF