P36252

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tmw:THMA_0469
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36252

Entry ID Method Resolution Chain Position Source
AF-P36252-F1 Predicted AlphaFoldDB

No variants for P36252

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P36252

No associated diseases with P36252

8 regional properties for P36252

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 635 - 674 IPR000722-1
domain RNA polymerase, alpha subunit 683 - 778 IPR000722-2
domain RNA polymerase, N-terminal 519 - 807 IPR006592
domain RNA polymerase Rpb1, domain 3 782 - 931 IPR007066
domain RNA polymerase Rpb1, domain 1 8 - 143 IPR007080-1
domain RNA polymerase Rpb1, domain 1 465 - 633 IPR007080-2
domain RNA polymerase Rpb1, domain 5 1059 - 1509 IPR007081
domain RNA polymerase Rpb1, domain 4 961 - 1026 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPMSSFKRKI KAIQIKIASP EVIRSWSGGE VKKPETINYR TFKPERDGLF CERIFGPVKD
70 80 90 100 110 120
YECACGKYKG KKYEGTVCER CGVRVESREA RRKRMGHIEL AAPAVHIWYL ESIPSVLGTL
130 140 150 160 170 180
LNMSTSDLEN IIYYGSRRVI ERAFIVTDPK DTPFSQGDVI YETEYRIYRK KWDFDVEQAF
190 200 210 220 230 240
VVKNPKSPVL SDIDGEVTLK TEKSITGREI TWIIVKNITR ATHTVLPGMI LVVKDGQEVE
250 260 270 280 290 300
KGQDLTKEMT IDPVYAPFDG HVEIDELSNT ITLKPLTTSK DQPVVFTIPY GAKILVSNGQ
310 320 330 340 350 360
KVKKGDQITT STSLPAVKAS ISGTVRFGSN LNIRALEDGN FEVLSTGEVY VEQVIEERKY
370 380 390 400 410 420
PVFEGALVYV NNGDQVKKGD HLADRFLFEE EYLSATEYKI FESHYPTMFD VEERTENDRP
430 440 450 460 470 480
IVVITDIDPE VSKETGLKVG DIVTENEYEA YLQIYPEKIV ADAGAQAIKK LLQNLDLEAL
490 500 510 520 530 540
QAEIEAELKK LPSSSSKAIK LRRRLKMVKD FLKSGNKPEW MVLEVVPVIP PDLRPMIQIE
550 560 570 580 590 600
GGRFATTDLN ELYRRLINRN NRLKKLLELG APEIILRNEK RMLQEAVDAL IHNGSDSEGK
610 620 630 640 650 660
RSRRAVLKDR NGRPLKSLTD LLKGKKGRFR RNLLGKRVDY SGRAVIVVGP NLKIHQCGIP
670 680 690 700 710 720
KKMAMELFKP FVLAKLLGEG SSSKTMRKVK KAIIEKEMPE AWEVLEEVIK GSVVLLNRAP
730 740 750 760 770 780
TLHRMSIQAF EPKLVEGNAI QLHPVVCPPF NADFDGDQMA VHVPLSAAAQ AEARFLMLSR
790 800 810 820 830 840
YNIISPAHGK PISLPTQDII IGSYYLTTVG KEFDSLKEED VKWKFSSPEE AMLAYHLGFI
850 860 870 880 890 900
KLHTPILIKV AVNGEEKRIK TTLGRVIFNG ILPEDLRDYN RIFDKKQINA LVYETFKRHG
910 920 930 940 950 960
IDRAADLLDD IKDIGFHYAT VSGLTLSLKD LKIPPERDEI LRKTWEKVRI IEENYEKGFL
970 980 990 1000 1010 1020
TEEQRKSEII RLWMSVTEEI TKLTSKTLAE DPFNPIYMMV NSGARGNIDQ VKQLAGIRGL
1030 1040 1050 1060 1070 1080
MIKAYDPRSR EIKSKIFKGQ AIHEALTFDY PVDKNLREGV DILQFFISTY GARKGQVDTA
1090 1100 1110 1120 1130 1140
MNTSFAGYLT RRLVDVAQSV TVAEPDCGTH EGIRAMDLIK EGTVVEKMNE FLFGRVLARD
1150 1160 1170 1180 1190 1200
VLDPETKEVL KNPETGKEYT RNTMLTDDDA NFLASYKKMV DVVRYEEIDI TELSLPNMYA
1210 1220 1230 1240 1250 1260
EIAEPVGEYE EGTELTWDVI KAAKNEGKYR IKVKVYPVVG TVYAEEEPLY DKKGERQLLV
1270 1280 1290 1300 1310 1320
YQEVINEIVA KMLEENGIEK VSVRPDIIVR SPLTCESEYG VCAACYGMDL SNHKIVNVGE
1330 1340 1350 1360 1370 1380
AVGVVAAQSI GEPGTQLTMR TFHVGGVMGA SDIVSGLTTV EKTFEPYAFL REEKSGGKKE
1390 1400 1410 1420 1430 1440
IRKYYGSEAI LCEVDGFVKD IATDESGRTV IYIEDYAGNI HAYKVPKRAK VRVEKGQKVL
1450 1460 1470 1480 1490 1500
RGETLTSGAI VWWKLLELES EKGVMTAMNL LKIIKNAYVQ QGVSIHDKHF EIIFKQMLSM
1510 1520 1530 1540 1550 1560
ATIVDPGDSD YLPDQLVPLV DIKRFNREIL EGNAKVEENR KWVIGKTLAK RIITETEEGE
1570 1580 1590 1600 1610 1620
LVELAQKGDE VTEELLKKII EAGIKEIDVF EKDKVVTYQI LPKEPIKYKR RLLSLKKAAL
1630 1640 1650 1660 1670 1680
NYPGWLSAAA FEETAWVLTA AAIEGKVDPL IGLKENVIVG QLIPAGTGLD VFAGIQVEET
PRAAVEEELA