P36204

PR
Gene name
pgk/tpi (TM_0689)
Protein name
Bifunctional PGK/TIM
Names
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM0689
EC number
2.7.2.3: Phosphotransferases with a carboxy group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

330-399 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P36204

Entry ID Method Resolution Chain Position Source
1B9B X-ray 285 A A/B 400-654 PDB
1VPE X-ray 200 A A 2-398 PDB
AF-P36204-F1 Predicted AlphaFoldDB

No variants for P36204

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P36204

No associated diseases with P36204

2 regional properties for P36204

Type Name Position InterPro Accession
conserved_site Phosphoglycerate kinase, conserved site 15 - 25 IPR015911
active_site Triosephosphate isomerase, active site 565 - 575 IPR020861

Functions

Description
EC Number 2.7.2.3 Phosphotransferases with a carboxy group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoglycerate kinase activity Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+).
triose-phosphate isomerase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.

3 GO annotations of biological process

Name Definition
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKMTIRDVD LKGKRVIMRV DFNVPVKDGV VQDDTRIRAA LPTIKYALEQ GAKVILLSHL
70 80 90 100 110 120
GRPKGEPSPE FSLAPVAKRL SELLGKEVKF VPAVVGDEVK KAVEELKEGE VLLLENTRFH
130 140 150 160 170 180
PGETKNDPEL AKFWASLADI HVNDAFGTAH RAHASNVGIA QFIPSVAGFL MEKEIKFLSK
190 200 210 220 230 240
VTYNPEKPYV VVLGGAKVSD KIGVITNLME KADRILIGGA MMFTFLKALG KEVGSSRVEE
250 260 270 280 290 300
DKIDLAKELL EKAKEKGVEI VLPVDAVIAQ KIEPGVEKKV VRIDDGIPEG WMGLDIGPET
310 320 330 340 350 360
IELFKQKLSD AKTVVWNGPM GVFEIDDFAE GTKQVALAIA ALTEKGAITV VGGGDSAAAV
370 380 390 400 410 420
NKFGLEDKFS HVSTGGGASL EFLEGKELPG IASIADKKKI TRKLILAGNW KMHKTISEAK
430 440 450 460 470 480
KFVSLLVNEL HDVKEFEIVV CPPFTALSEV GEILSGRNIK LGAQNVFYED QGAFTGEISP
490 500 510 520 530 540
LMLQEIGVEY VIVGHSERRR IFKEDDEFIN RKVKAVLEKG MTPILCVGET LEEREKGLTF
550 560 570 580 590 600
CVVEKQVREG FYGLDKEEAK RVVIAYEPVW AIGTGRVATP QQAQEVHAFI RKLLSEMYDE
610 620 630 640 650
ETAGSIRILY GGSIKPDNFL GLIVQKDIDG GLVGGASLKE SFIELARIMR GVIS