P36203

PR
Gene name
recA
Protein name
Protein RecA
Names
Recombinase A
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM1859
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

307-356 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P36203

Entry ID Method Resolution Chain Position Source
3HR8 X-ray 195 A A 1-356 PDB
AF-P36203-F1 Predicted AlphaFoldDB

No variants for P36203

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P36203

No associated diseases with P36203

4 regional properties for P36203

Type Name Position InterPro Accession
domain AAA+ ATPase domain 58 - 229 IPR003593
conserved_site DNA recombination/repair protein RecA, conserved site 214 - 222 IPR020584
domain DNA recombination and repair protein RecA, monomer-monomer interface 200 - 273 IPR020587
domain DNA recombination and repair protein RecA-like, ATP-binding domain 36 - 195 IPR020588

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
single-stranded DNA binding Binding to single-stranded DNA.

3 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEEKQKKSV LEKALKRIEE NFGKGSIMIL GDETQVQPVE VIPTGSLAID IATGVGGYPR
70 80 90 100 110 120
GRIVEIFGQE SSGKTTLALH AIAEAQKMGG VAAFIDAEHA LDPVYAKNLG VDLKSLLISQ
130 140 150 160 170 180
PDHGEQALEI VDELVRSGVV DLIVVDSVAA LVPRAEIEGA MGDMQVGLQA RLMSQALRKI
190 200 210 220 230 240
AGSVNKSKAV VIFTNQIRMK IGVMFGSPET TTGGLALKFY ATMRMEVRRG EPIKEGKDVI
250 260 270 280 290 300
GNVISVKIVK NKVAPPFKTA QTYIIYGKGI DREYELFNIA VNEGIVDRKG SWYYYTTLKG
310 320 330 340 350
EEVSLGQGSS NAVQFLKDNP EIAGEIERRI REKYGLLSVE KEEQRKEKKS SGEEAS