P36160

PR
Gene name
RPF2 (YKR081C, YKR401)
Protein name
Ribosome biogenesis protein RPF2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKR081C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

213-344 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

16 structures for P36160

Entry ID Method Resolution Chain Position Source
3JCT EM 308 A v 1-344 PDB
5A53 X-ray 240 A C 23-252 PDB
5WXL X-ray 190 A A/C 19-288 PDB
6FT6 EM 390 A v 1-344 PDB
6M62 EM 320 A v 1-254 PDB
7BT6 EM 312 A v 1-344 PDB
7BTB EM 322 A v 1-344 PDB
7OH3 EM 340 A v 1-344 PDB
7OHQ EM 310 A v 1-344 PDB
7OHT EM 470 A v 1-344 PDB
7UG6 EM 290 A v 1-344 PDB
7UOO EM 234 A v 1-344 PDB
7UQB EM 243 A v 1-344 PDB
7UQZ EM 244 A v 1-344 PDB
7V08 EM 236 A v 1-344 PDB
AF-P36160-F1 Predicted AlphaFoldDB

6 variants for P36160

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-592044 47 V>I No SGRP
s11-591989 65 D>V No SGRP
s11-591965 73 S>L No SGRP
s11-591717 156 Q>K No SGRP
s11-591554 210 K>R No SGRP
s11-591270 305 D>H No SGRP

No associated diseases with P36160

1 regional properties for P36160

Type Name Position InterPro Accession
conserved_site Ribosomal protein L22/L17, conserved site 126 - 150 IPR018260

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

3 GO annotations of molecular function

Name Definition
5S rRNA binding Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome.
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
rRNA binding Binding to a ribosomal RNA.

4 GO annotations of biological process

Name Definition
assembly of large subunit precursor of preribosome The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIRTVKPKNA RAKRALVKRE AKLVENVKQA LFIPGQSCNK NLHDIMVDLS ALKKPDMKRF
70 80 90 100 110 120
NRKNDIHPFE DMSPLEFFSE KNDCSLMVLM TSSKKRKNNM TFIRTFGYKI YDMIELMVAD
130 140 150 160 170 180
NFKLLSDFKK LTFTVGLKPM FTFQGAAFDT HPVYKQIKSL FLDFFRGEST DLQDVAGLQH
190 200 210 220 230 240
VISMTIQGDF QDGEPLPNVL FRVYKLKSYK SDQGGKRLPR IELVEIGPRL DFKIGRIHTP
250 260 270 280 290 300
SPDMVTEAHK KPKQLEMKTK KNVELDIMGD KLGRIHMGKQ DLGKLQTRKM KGLKSKFDQG
310 320 330 340
TEEGDGEVDE DYEDEASYSD DGQEYEEEFV SATDIEPSAK RQKK