AiPD: Autoinhibited Protein Database

Gene name	TFA2 (YKR062W)
Protein name	Transcription initiation factor IIE subunit beta
Names	TFIIE-beta, Factor A 43 kDa subunit, Transcription factor A small subunit
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YKR062W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-147 (Predicted disordered autoinhibitory region) PR

1-147 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5FMF	EM	600 A	S	125-247	PDB
5FYW	EM	435 A	X	1-328	PDB
5FZ5	EM	880 A	X	1-328	PDB
5OQJ	EM	470 A	X	1-328	PDB
5OQM	EM	580 A	X	1-328	PDB
5SVA	EM	1530 A	i	1-328	PDB
6GYL	EM	480 A	X	1-328	PDB
6GYM	EM	670 A	X	1-328	PDB
7ML0	EM	300 A	X	1-328	PDB
7ML1	EM	400 A	X	1-328	PDB
7ML2	EM	340 A	X	1-328	PDB
7ML4	EM	310 A	X	1-328	PDB
7O4I	EM	320 A	X	1-328	PDB
7O4J	EM	290 A	X	1-328	PDB
7O4K	EM	360 A	X	1-328	PDB
7O4L	EM	340 A	X	1-328	PDB
7O72	EM	340 A	X	1-328	PDB
7O73	EM	340 A	X	1-328	PDB
7O75	EM	320 A	X	1-328	PDB
7ZS9	EM	310 A	X	1-328	PDB
7ZSA	EM	400 A	X	1-328	PDB
7ZSB	EM	660 A	X	1-328	PDB
8CEN	EM	300 A	X	1-328	PDB
8CEO	EM	360 A	X	1-328	PDB
AF-P36145-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
s11-559512	69	V>M		No	SGRP

Type	Name	Position	InterPro Accession
domain	Transcription factor TFIIE beta subunit, DNA-binding domain	113 - 187	IPR003166
domain	TFA2, Winged helix domain 2	188 - 247	IPR040501

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIE complex	A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.
transcription preinitiation complex	A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Name	Definition
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription initiation at RNA polymerase II promoter	A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P29084	GTF2E2	Transcription initiation factor IIE subunit beta	Homo sapiens (Human)	PR