AiPD: Autoinhibited Protein Database

Gene name	RPC37 (YKR025W)
Protein name	DNA-directed RNA polymerase III subunit RPC5
Names	RNA polymerase III subunit C5, DNA-directed RNA polymerase III 37 kDa polypeptide, RNA polymerase III subunit C37
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YKR025W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-87 (Predicted disordered autoinhibitory region) PR

1-87 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5FJ8	EM	390 A	M	1-282	PDB
5FJ9	EM	460 A	M	1-282	PDB
5FJA	EM	465 A	M	1-282	PDB
6CNB	EM	410 A	M	1-282	PDB
6CNC	EM	410 A	M	1-282	PDB
6CND	EM	480 A	M	1-282	PDB
6CNF	EM	450 A	M	1-282	PDB
6EU0	EM	400 A	M	1-282	PDB
6EU1	EM	340 A	M	1-282	PDB
6EU2	EM	340 A	M	1-282	PDB
6EU3	EM	330 A	M	1-282	PDB
6F40	EM	370 A	M	1-282	PDB
6F41	EM	430 A	M	1-282	PDB
6F42	EM	550 A	M	1-282	PDB
6F44	EM	420 A	M	1-282	PDB
6TUT	EM	325 A	M	1-282	PDB
7Z0H	EM	260 A	M	1-282	PDB
7Z1L	EM	280 A	M	1-282	PDB
7Z1M	EM	340 A	M	1-282	PDB
7Z1O	EM	270 A	M	1-282	PDB
7Z2Z	EM	307 A	M	1-282	PDB
7Z30	EM	290 A	M	1-282	PDB
7Z31	EM	276 A	M	1-282	PDB
8BWS	EM	320 A	M	1-282	PDB
AF-P36121-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s11-487460	16	D>E	No	SGRP
s11-487486	25	E>G	No	SGRP
s11-487495	28	S>F	No	SGRP
s11-487548	46	N>D	No	SGRP
s11-487643	77	K>N	No	SGRP
s11-488161	250	G>D	No	SGRP
s11-488212	267	T>S	No	SGRP

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P36121

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase III complex	RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

Name	Definition
No GO annotations for molecular function

Name	Definition
termination of RNA polymerase III transcription	A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.
transcription by RNA polymerase III	The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
transcription initiation at RNA polymerase III promoter	A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.
tRNA transcription by RNA polymerase III	The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins