P36075
Gene name |
CUE2 (YKL090W) |
Protein name |
Ubiquitin-binding protein CUE2 |
Names |
Coupling of ubiquitin conjugation to ER degradation protein 2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL090W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P36075
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1OTR | NMR | - | A | 6-54 | PDB |
| AF-P36075-F1 | Predicted | AlphaFoldDB |
12 variants for P36075
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-271849 | 110 | P>S | No | SGRP | |
| s11-271964 | 148 | A>V | No | SGRP | |
| s11-272138 | 206 | G>D | No | SGRP | |
| s11-272155 | 212 | V>F | No | SGRP | |
| s11-272179 | 220 | P>S | No | SGRP | |
| s11-272222 | 234 | E>V | No | SGRP | |
| s11-272244 | 241 | D>E | No | SGRP | |
| s11-272293 | 258 | Q>* | No | SGRP | |
| s11-272353 | 278 | D>N | No | SGRP | |
| s11-272384 | 288 | D>A | No | SGRP | |
| s11-272455 | 312 | S>P | No | SGRP | |
| s11-272672 | 384 | N>S | No | SGRP |
No associated diseases with P36075
5 regional properties for P36075
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Smr domain | 344 - 443 | IPR002625 |
| domain | Ubiquitin system component CUE | 8 - 51 | IPR003892-1 |
| domain | Ubiquitin system component CUE | 55 - 98 | IPR003892-2 |
| domain | Ubiquitin-binding protein Cue2, CUE domain 1 | 10 - 51 | IPR041809 |
| domain | Ubiquitin-binding protein Cue2, CUE domain 2 | 57 - 94 | IPR041810 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA cleavage | Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. |
| nuclear-transcribed mRNA catabolic process, no-go decay | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSMDNNDDHE | SKLSILMDMF | PAISKSKLQV | HLLENNNDLD | LTIGLLLKEN | DDKSTVDNEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HQLYDMFPQL | DCSVIKDQFV | INEKSVESTI | SDLLNYETLQ | KLKDNQANSP | DSVKRNEKKN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NWESTNDHIE | SIIKFTDAPK | NIAQEYLAEN | GFDTVKAIIK | IILDYYDKRD | FKKDVDTFKV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRSPNTTVRG | GRVQSSTGLA | HVLKKGKESA | NVAQESLKRP | RSYKHSLDSP | QMVELNELVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DNRDLKAINH | EFLQKCLQFY | DGDVVKVLNI | SSLLIEDDKN | ITKTWNFDEG | FTLTSRDNCK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QHLPKFSTPQ | ISRRNEVGNT | YKLPLHDKET | PEGAVPVINN | LFQTYRLDFH | GFLPSEAVST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKLALNKWWS | KEVAERELNS | HNINSYGSKV | QFVSPLIVVT | GRGIHSIGGI | SKVRLQVKSF |
| 430 | 440 | ||||
| LEKNHYIFWE | ESSYFRIEGK | KKK |