P36070

PR
Gene name
RRN3 (YKL125W)
Protein name
RNA polymerase I-specific transcription initiation factor RRN3
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKL125W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

16 structures for P36070

Entry ID Method Resolution Chain Position Source
3TJ1 X-ray 285 A A/B 1-627 PDB
5G5L EM 480 A O 1-627 PDB
5N5Y EM 770 A O 1-627 PDB
5N5Z EM 770 A O 1-627 PDB
5N60 EM 770 A O 1-627 PDB
5N61 EM 340 A O 1-627 PDB
5OA1 EM 440 A O 1-627 PDB
6RQH EM 370 A O 1-627 PDB
6RQL EM 290 A O 1-627 PDB
6RQT EM 400 A O 1-627 PDB
6RRD EM 310 A O 1-627 PDB
6RUI EM 270 A O 1-627 PDB
6RUO EM 350 A O 1-627 PDB
6RWE EM 300 A O 1-627 PDB
6TPS EM 354 A O 1-627 PDB
AF-P36070-F1 Predicted AlphaFoldDB

10 variants for P36070

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-208167 93 L>F No SGRP
s11-208283 131 H>Q No SGRP
s11-208359 157 I>L No SGRP
s11-208389 167 K>E No SGRP
s11-208731 281 E>K No SGRP
s11-208779 297 G>R No SGRP
s11-208819 310 G>D No SGRP
s11-208909 340 S>T No SGRP
s11-208928 346 Q>H No SGRP
s11-209119 410 V>A No SGRP

No associated diseases with P36070

No regional properties for P36070

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P36070

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
rDNA binding Binding to a DNA sequence encoding a ribosomal RNA.
RNA polymerase I core binding Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
RNA polymerase I general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.
RNA polymerase I general transcription initiation factor binding Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I.

1 GO annotations of biological process

Name Definition
transcription initiation at RNA polymerase I promoter A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMAFENTSKR PPQDFVAPID QKKRKVQFSD STGLVTLQPE EIKDEVFSAA MYSRFVKSAL
70 80 90 100 110 120
DDLDKNDSTQ IGIIANQVAL PSKNPERIND KNLNILLDIL SSNINRIESS RGTFLIQSII
130 140 150 160 170 180
NFEKWWELPP HTLSKYIYFI KILCSSIPKW WQDVSMILVS CFILPIKQTV CHHDMLKYFL
190 200 210 220 230 240
RMIPSSMGFI DTYLAKFFPN KNDTRRKLVN YTSNLLKLRG YCSELGFQIW SLLIEKIISI
250 260 270 280 290 300
DVELQNELDE LDDDVDDDDL EEVDLEDDDD LDDDSGDDDD ENCGNSNEEL RSGAADGSQS
310 320 330 340 350 360
DSEDMDIIEG MDGTEEYNVE LTQGIKELST KLDSILTLVS THVEEQVTPE SLESGEGVGV
370 380 390 400 410 420
FNTLTTLFKT HVLPTYYTRS IQYIMFHVSQ QQLELMDSFL VTLIDISFAV NEAAEKKIKS
430 440 450 460 470 480
LQYLGSYIAR AKKLSRTQII FVASYLTSWL NRYVIEREEE VDQRGGMERF KHFYAAFQAL
490 500 510 520 530 540
CYIFCFRHNI FRDTDGNWEC ELDKFFQRMV ISKFNPLKFC NENVMLMFAR IAQQESVAYC
550 560 570 580 590 600
FSIIENNNNE RLRGIIGKAD SDKKENSAQA NTTSSSWSLA TRQQFIDLQS YFPYDPLFLK
610 620
NYKILMKEYY IEWSEASGEY ESDGSDD