P36066
Gene name |
YKL133C |
Protein name |
Protein MRG3-like |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL133C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36066
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36066-F1 | Predicted | AlphaFoldDB |
8 variants for P36066
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-192717 | 118 | E>G | No | SGRP | |
| s11-192712 | 120 | V>M | No | SGRP | |
| s11-192705 | 122 | L>P | No | SGRP | |
| s11-192409 | 221 | N>Y | No | SGRP | |
| s11-192186 | 295 | S>N | No | SGRP | |
| s11-192079 | 331 | I>F | No | SGRP | |
| s11-192037 | 345 | A>T | No | SGRP | |
| s11-191872 | 400 | M>V | No | SGRP |
No associated diseases with P36066
No regional properties for P36066
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P36066 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| i-AAA complex | Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| misfolded protein binding | Binding to a misfolded protein. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein quality control for misfolded or incompletely synthesized proteins | The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWKYLHRSVK | NEGTVERLTN | LNLFTNHRFK | FYSTLKEQSF | WRIPFKRRSK | LQKWVLSTGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VSFIAFNIWW | VYWPHHTFPK | PVAKILRKGL | HSEIKKEGAN | YQKSLEYYLE | ALEECKAENV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLLSDEYTGI | EIKIGEMYEK | LHMYNDATAL | YGDMLKKFYN | ELSKTTDKST | KRKFFLLKRD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQILVRFNEI | NKDSETNATL | LIMHLLLAQR | EFLENSPEFK | NVLSKSELLN | NQQLDWKNFK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLPFIGKSKP | DYQMHLNSKR | KQELKIKEPE | SEQCVFMKEL | LTARDLYTRY | CLNRSNLSGA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNSKITTLEW | MLLADSPLDD | ILLAQAELGS | IFYLNSEKFE | GSLYAIDNEP | YKKSEPLELI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RSRLQENQNS | CLQYSADCYK | SIISFANENQ | YPKVAMESEM | DQRILKALSL | AHYGIGVINL |
| 430 | 440 | 450 | 460 | ||
| HKGRLRASKK | ELKKAIRISE | MIRFNELIEE | AQRELKKVDG | TPI |